SERPINB2
SERPINB2 (serpin family B member 2), also known as plasminogen activator inhibitor 2, PAI-2, PAI2, PLANH2 or HsT1201, is a member of the ov-serpin subfamily. It inhibits urokinase-type plasminogen activator and is distinct from the endothelial cell-derived PAI-1. Browse Assay Genie's current range of SERPINB2 research reagents below, or read on for the biology behind the target.
SERPINB2 is a serine protease inhibitor whose best-defined activity is the inhibition of urokinase-type plasminogen activator. Because that enzyme sits in the plasminogen activation pathway, the SERPINB2 protein is of interest in studies of fibrinolysis. NCBI Gene annotation also predicts that it has serine-type endopeptidase inhibitor activity and a role in the negative regulation of the apoptotic process. These are computational predictions and not experimentally confirmed functions.
The protein is annotated as localising to the cytoplasm and to the extracellular space, and it is also predicted to be present in the plasma membrane. UniProt places it in the serpin family, ov-serpin subfamily, and HGNC lists the SERPINB2 gene within the group of serpin peptidase inhibitors. The mouse and rat orthologues are both named Serpinb2, which allows comparative work across these species.
SERPINB2 is widely known as plasminogen activator inhibitor 2 (PAI-2). The UniProt entry specifies that the monocyte-derived PAI-2 is distinct from the endothelial cell-derived PAI-1, a point worth keeping in mind when interpreting literature on plasminogen activator inhibitors. Earlier gene names were serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 and serpin peptidase inhibitor, clade B (ovalbumin), member 2, which reflect its relationship to the ovalbumin-type serpins. Other aliases include PLANH2 and HsT1201. Researchers working on SERPINB2 often compare it with other clade B serpins.
SERPINB2 inhibits urokinase-type plasminogen activator, making it relevant to studies of plasminogen activation and fibrinolysis.
As an ov-serpin family member, SERPINB2 is a useful subject for comparing clade B serpin function and nomenclature.
SERPINB2 is predicted to be involved in negative regulation of the apoptotic process, which motivates investigation of cell survival mechanisms.
Monocyte-derived PAI-2 is distinct from endothelial PAI-1, so SERPINB2 supports work separating the roles of different plasminogen activator inhibitors.
SERPINB2 inhibits urokinase-type plasminogen activator. NCBI Gene also predicts serine-type endopeptidase inhibitor activity, involvement in fibrinolysis and negative regulation of the apoptotic process. It is found in the cytoplasm and the extracellular space.
SERPINB2 is also called plasminogen activator inhibitor 2, PAI-2, PAI2, PLANH2 and HsT1201. Previous names include serpin peptidase inhibitor, clade B (ovalbumin), member 2. Check the datasheet of any product for its validated reactivity.
Both are plasminogen activator inhibitors, but UniProt notes that the monocyte-derived PAI-2 (SERPINB2) is distinct from the endothelial cell-derived PAI-1. They are separate proteins. SERPINB2 belongs to the ov-serpin subfamily, and mouse and rat have orthologues named Serpinb2.
Other clade B serpins that sit alongside SERPINB2 in the serpin peptidase inhibitor group.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05120; product specifications from Assay Genie datasheets.