HDAC7
HDAC7 (histone deacetylase 7, previously histone deacetylase 7A or HDAC7A) is a class IIa histone deacetylase that removes acetyl groups from lysine residues on core histones. It acts as a transcriptional corepressor in muscle differentiation, immune signalling and gene regulation. Browse Assay Genie's current range of HDAC7 research reagents below, or read on for the biology behind the target.
HDAC7 is responsible for deacetylating lysine residues on the N-terminal part of the core histones H2A, H2B, H3 and H4. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Like other histone deacetylases, it acts through the formation of large multiprotein complexes. Histone acetylation and deacetylation alter chromosome structure and affect transcription factor access to DNA.
In muscle, HDAC7 is involved in maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation it shuttles into the cytoplasm, which allows these factors to be expressed. HDAC7 also positively regulates the transcriptional repressor activity of FOXP3, and serves as a corepressor of RARA, causing its deacetylation and inhibiting RARE DNA element binding. In association with RARA, it contributes to repression of microRNA-10a and thereby to the inflammatory response. It may also be involved in Epstein-Barr virus latency, possibly by repressing the viral BZLF1 gene, and it acetylates non-histone proteins such as ALKBH5.
The HDAC7 gene encodes a member of the histone deacetylase family, assigned to the HD type 2 subfamily and to HGNC's class IIA histone deacetylases and NCoR/SMRT transcriptional repression complex subunits. The gene is orthologous to mouse Hdac7, whose protein promotes repression mediated by the corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been reported. Aliases include DKFZP586J0917 and HDAC7A.
HDAC7 deacetylates core histones, marking chromatin for epigenetic repression and shaping transcriptional regulation, cell cycle progression and developmental events.
HDAC7 represses MEF2A, MEF2B and MEF2C, and its shuttling into the cytoplasm during differentiation permits myocyte enhancer factor expression.
With RARA, HDAC7 represses microRNA-10a and contributes to the inflammatory response, and it positively regulates FOXP3 repressor activity.
HDAC7 may be involved in Epstein-Barr virus latency, possibly by repressing the viral BZLF1 gene.
HDAC7 deacetylates lysine residues on the N-terminal tails of core histones H2A, H2B, H3 and H4, tagging chromatin for epigenetic repression. It also represses MEF2 transcription factors in muscle, corepresses RARA, and acetylates non-histone proteins such as ALKBH5.
HDAC7 was previously named histone deacetylase 7A, with the aliases HDAC7A and DKFZP586J0917. NCBI Gene reports that alternatively spliced transcript variants encode different isoforms. Check the datasheet of any product for its validated reactivity and isoform coverage.
Yes. The human HDAC7 gene is orthologous to mouse Hdac7, and a rat Hdac7 ortholog also exists. The mouse protein promotes repression mediated by the transcriptional corepressor SMRT, consistent with the human gene's place among NCoR/SMRT repression complex subunits.
Other class IIa histone deacetylases and further HDAC family members involved in chromatin and transcriptional regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WUI4; product specifications from Assay Genie datasheets.