ABCB5
ABCB5 (ATP-binding cassette sub-family B member 5) is an energy-dependent efflux transporter of the plasma membrane that contributes to decreased drug accumulation in multidrug-resistant cells. It is also known as ABCB5alpha, ABCB5beta and EST422562. Browse Assay Genie's current range of ABCB5 research reagents below, or read on for the biology behind the target.
ABCB5 is an energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. As a member of the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins, it takes part in ATP-dependent transmembrane transport. The superfamily as a whole moves structurally diverse molecules across membranes, from small ions, sugars and peptides to more complex organic molecules. The protein is found at the cell membrane.
UniProt reports that ABCB5 is specifically present in limbal stem cells, where it plays a key role in corneal development and repair. This links a multidrug-resistance-type exporter to a defined stem cell population, and makes the ABCB5 protein a point of interest for both drug-efflux and ocular surface biology.
The ABCB5 gene belongs to the ABCB family and to the multidrug resistance exporter subfamily (TC 3.A.1.201) of the ABC transporter superfamily. HGNC classifies it in the ATP binding cassette subfamily B gene group, and its previous name was ATP-binding cassette, sub-family B (MDR/TAP), member 5. Alternative designations include ABCB5alpha, ABCB5beta and EST422562. A mouse ortholog, Abcb5, is recorded. Related family members include ABCB1, ABCB4, ABCB9 and ABCB11.
ABCB5 is an efflux transporter linked to decreased drug accumulation in multidrug-resistant cells, making it relevant to studies of how cells export drugs.
ABCB5 is specifically present in limbal stem cells, so it is studied as a protein associated with this stem cell population.
UniProt assigns ABCB5 a key role in corneal development and repair, which supports its use in ocular surface research.
As an integral membrane ABC transporter, ABCB5 contributes to work on ATP-dependent transmembrane transport and on the ABCB subfamily.
ABCB5 is an energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. It is specifically present in limbal stem cells, where it plays a key role in corneal development and repair. It localises to the cell membrane.
The HGNC name is ATP binding cassette subfamily B member 5, and the earlier name was ATP-binding cassette, sub-family B (MDR/TAP), member 5. Aliases include EST422562, ABCB5alpha and ABCB5beta. UniProt lists the protein as ATP-binding cassette sub-family B member 5.
A mouse ortholog, Abcb5, is recorded for the human gene. ABCB5 belongs to the ABCB family of the ABC transporter superfamily, within the multidrug resistance exporter subfamily. Check the datasheet of any product for its validated reactivity.
Other ABCB family transporters and multidrug-resistance-related ABC proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q2M3G0; product specifications from Assay Genie datasheets.