PDE4B
PDE4B (phosphodiesterase 4B, also known as DPDE4) is a cAMP-specific cyclic nucleotide phosphodiesterase of the PDE4 subfamily. It hydrolyses the second messenger cAMP and so helps shape intracellular signal transduction. Browse Assay Genie's current range of PDE4B research reagents below, or read on for the biology behind the target.
PDE4B hydrolyses cAMP, a second messenger that is a key regulator of many important physiological processes. By breaking down this cyclic nucleotide, the enzyme regulates cellular cyclic nucleotide concentrations and therefore plays a role in signal transduction. UniProt annotates it as 3',5'-cyclic-AMP phosphodiesterase 4B, and it is assigned EC 3.1.4.53. It is found in the cytoplasm and at the cell membrane.
The PDE4B gene belongs to the type IV, cAMP-specific family of cyclic nucleotide phosphodiesterases, and the protein is a member of the PDE4 subfamily. HGNC classes it within the phosphodiesterases gene group. Alternative splicing and the use of alternative promoters give rise to multiple transcript variants that encode different isoforms, so work on the PDE4B protein often needs to consider which isoform is being studied. The rat ortholog is Pde4b.
The gene's earlier names refer to the Drosophila dunce gene, because the protein is a homolog of the fly phosphodiesterase E4 enzyme. Altered PDE4B activity has been associated with schizophrenia and bipolar affective disorder. UniProt also notes that the enzyme may be involved in mediating the central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. This makes PDE4B a recurring subject in studies of cAMP signalling, neuropsychiatric disease and inflammation.
PDE4B hydrolyses cAMP and regulates cellular cyclic nucleotide concentrations, making it a direct modulator of second messenger signalling.
Altered PDE4B activity has been associated with schizophrenia and bipolar affective disorder, which motivates its study in the central nervous system.
PDE4B may mediate the effects of antiasthmatic and anti-inflammatory agents, so it is relevant to research on those therapeutic classes.
UniProt notes a possible role in the central nervous system effects of therapeutic agents, including antidepressants.
PDE4B hydrolyses the second messenger cAMP, which regulates many important physiological processes. In doing so it controls cellular cyclic nucleotide concentrations and contributes to signal transduction. It is a cAMP-specific enzyme of the PDE4 subfamily and is found in the cytoplasm and at the cell membrane.
PDE4B is also known as DPDE4, and its earlier HGNC names describe it as a cAMP-specific dunce homolog phosphodiesterase E4. Alternative splicing and alternative promoters produce multiple transcript variants that encode different isoforms, so check which isoform is relevant to your work.
NCBI Gene reports that altered PDE4B activity has been associated with schizophrenia and bipolar affective disorder. UniProt adds that it may mediate central nervous system effects of antidepressants, antiasthmatic and anti-inflammatory agents. The rat ortholog is Pde4b; check the datasheet of any product for its validated reactivity.
Other PDE4 subfamily members and further cyclic nucleotide phosphodiesterases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q07343; product specifications from Assay Genie datasheets.