PDCD10
PDCD10 (programmed cell death 10, also known as CCM3 and TFAR15) is an evolutionarily conserved protein that promotes cell proliferation, modulates apoptotic pathways and supports vascular development. It is a component of STRIPAK complexes and of the CCM adhesion complex. Browse Assay Genie's current range of PDCD10 research reagents below, or read on for the biology behind the target.
PDCD10 promotes cell proliferation and modulates apoptotic pathways. It increases mitogen-activated protein kinase activity and the activity of STK26, and it is important for cell migration and for the normal structure and assembly of the Golgi complex. The protein is part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes, which have critical roles in protein (de)phosphorylation and regulate several signalling pathways, including Hippo, MAPK, nuclear receptor and cytoskeleton remodelling. Different STRIPAK complexes contribute to cell growth, differentiation, apoptosis, metabolism and immune regulation.
PDCD10 is also important for KDR/VEGFR2 signalling, where it increases receptor stability and prevents its breakdown. It is required for normal cardiovascular development, and for angiogenesis, vasculogenesis and haematopoiesis during embryonic development. According to the NCBI Gene summary, the protein interacts with the serine/threonine kinase MST4 to modulate the ERK pathway, and it interacts with and is phosphorylated by serine/threonine kinase 25. It is thought to act in a signalling pathway essential for vascular development. UniProt places the protein in the PDCD10 family and reports it in the cytoplasm, the Golgi apparatus membrane and the cell membrane.
The PDCD10 gene was previously named cerebral cavernous malformations 3 (CCM3), and TFAR15 is a further alias. HGNC lists it within the STRIPAK complex and CCM adhesion complex gene groups. Mutations in the gene are one cause of cerebral cavernous malformations, vascular malformations that cause seizures and cerebral haemorrhages. Several alternatively spliced variants have been identified, all encoding the same protein. Mouse and rat both carry a Pdcd10 ortholog.
Mutations in PDCD10 are one cause of cerebral cavernous malformations, making it a key gene for studying these vascular lesions.
PDCD10 is required for normal angiogenesis, vasculogenesis and cardiovascular development, and it stabilises KDR/VEGFR2 signalling.
As a STRIPAK component, PDCD10 links to kinase and phosphatase regulation of Hippo, MAPK, nuclear receptor and cytoskeletal pathways.
PDCD10 modulates apoptotic pathways, cell proliferation and migration, and is important for normal Golgi structure and assembly.
PDCD10 promotes cell proliferation, modulates apoptotic pathways and is important for cell migration and Golgi assembly. It increases MAPK and STK26 activity, stabilises KDR/VEGFR2, and is required for cardiovascular development, angiogenesis, vasculogenesis and embryonic haematopoiesis. It is also part of STRIPAK complexes.
CCM3 comes from the previous name cerebral cavernous malformations 3, reflecting the link between PDCD10 mutations and these vascular malformations. TFAR15 is another alias. The official HGNC symbol is PDCD10, for programmed cell death 10. Alternative splicing yields variants that encode the same protein.
The NCBI Gene summary describes PDCD10 as evolutionarily conserved, and mouse and rat each have a Pdcd10 ortholog. Its roles in vascular development are reported in embryonic development. Check the datasheet of any product for its validated reactivity.
Other programmed cell death proteins with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BUL8; product specifications from Assay Genie datasheets.