CNN1
CNN1 (calponin 1) is a thin filament-associated protein implicated in the regulation and modulation of smooth muscle contraction. It is also known as SMCC and Sm-Calp, and was previously named calponin 1, basic, smooth muscle. Browse Assay Genie's current range of CNN1 research reagents below, or read on for the biology behind the target.
CNN1 is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity, which provides a mechanism by which the protein can restrain contractile activity at the thin filament.
The CNN1 gene encodes calponin-1, a member of the calponin family; it is classed in the HGNC Calponin family gene group, and the related gene CNN2 belongs to the same group. NCBI Gene summarises the protein as predicted to enable actin filament binding activity and as located in the cytoskeleton. Researchers studying the CNN1 protein often use it in the context of the smooth muscle contractile apparatus.
Beyond contraction, the gene is involved in the negative regulation of vascular associated smooth muscle cell proliferation. The official name is calponin 1, and the gene has also been referred to as SMCC and Sm-Calp, with the earlier name calponin 1, basic, smooth muscle. Mouse and rat both carry a Cnn1 ortholog, which allows the biology to be examined in common model organisms.
Calponin-1 is implicated in regulating and modulating smooth muscle contraction through its association with the thin filament.
CNN1 binds actin, and this interaction inhibits actomyosin Mg-ATPase activity, making it relevant to studies of thin filament function.
CNN1 is involved in negative regulation of vascular associated smooth muscle cell proliferation, linking it to vascular cell biology.
Calponin-1 binds calmodulin and tropomyosin as well as actin, so it is relevant to work on thin filament-associated protein complexes.
CNN1 is a thin filament-associated protein implicated in regulating and modulating smooth muscle contraction. It binds actin, calmodulin and tropomyosin, and its interaction with actin inhibits actomyosin Mg-ATPase activity. It is also involved in negative regulation of vascular associated smooth muscle cell proliferation.
The HGNC full name is calponin 1, and the UniProt protein name is calponin-1. Aliases include SMCC and Sm-Calp, and the previous name was calponin 1, basic, smooth muscle. The gene is classed in the Calponin family.
Yes. Mouse and rat each have a Cnn1 ortholog of the human CNN1 gene, so the protein can be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Other calponin family members and related thin filament-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P51911; product specifications from Assay Genie datasheets.