RPL7A
RPL7A (ribosomal protein L7a) is a component of the 60S large ribosomal subunit, which carries out protein synthesis in the cytoplasm. It is also known as SURF3, TRUP, L7A and eL8. Browse Assay Genie's current range of RPL7A research reagents below, or read on for the biology behind the target.
RPL7A is a component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Cytoplasmic ribosomes consist of a small 40S subunit and a large 60S subunit, which together contain four RNA species and approximately 80 structurally distinct proteins. The RPL7A protein is part of the 60S subunit.
The protein belongs to the eukaryotic ribosomal protein eL8 family, also described as the L7AE family of ribosomal proteins, and its UniProt name is large ribosomal subunit protein eL8. The RPL7A gene is classed by HGNC among the L ribosomal proteins and among the small nucleolar RNA protein coding host genes. It is co-transcribed with the U24, U36a, U36b and U36c small nucleolar RNA genes, which lie in its second, fifth, fourth and sixth introns respectively. The gene sits within the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. As is typical for ribosomal protein genes, multiple processed pseudogenes are dispersed through the genome. Mouse and rat both have an Rpl7a ortholog.
Beyond its ribosomal role, RPL7A can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor. In doing so it inhibits their ability to transactivate by preventing their binding to DNA response elements. The gene also rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein made of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. This accounts for the alias TRUP.
RPL7A is a 60S subunit protein, making it a relevant component for studying large ribosomal subunit composition and cytoplasmic protein synthesis.
RPL7A can bind a subclass of nuclear hormone receptors, including thyroid hormone receptor, and block their binding to DNA response elements.
The N terminus of RPL7A is fused to the trk kinase domain in the chimeric oncogene trk-2h, linking the gene to oncoprotein studies.
RPL7A is co-transcribed with U24, U36a, U36b and U36c snoRNA genes located in its introns, making it a model for host gene expression.
RPL7A is a component of the 60S large ribosomal subunit, part of the ribonucleoprotein complex that synthesises proteins in the cell. It can also interact with certain nuclear hormone receptors, including thyroid hormone receptor, and prevent them binding their DNA response elements, which inhibits transactivation.
RPL7A stands for ribosomal protein L7a. Aliases include SURF3, TRUP, L7A and eL8, and UniProt names the protein large ribosomal subunit protein eL8. SURF3 reflects its position in the surfeit gene cluster, while TRUP reflects its involvement in the trk-2h fusion oncogene.
Mouse and rat each have an Rpl7a ortholog; check the datasheet of any product for its validated reactivity. In humans, the gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein.
Other large subunit ribosomal proteins, including RPL and RPLP family members, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P62424; product specifications from Assay Genie datasheets.