FAM135B
FAM135B (family with sequence similarity 135 member B) is a human protein belonging to the FAM135 family, previously designated C8ORFK32. Its function has not been experimentally defined in the sources available, but it is predicted to be involved in lipid metabolic processes. Browse Assay Genie's current range of FAM135B research reagents below, or read on for the biology behind the target.
FAM135B is a protein-coding gene whose product, Protein FAM135B, is classed in the FAM135 family. No curated functional annotation is currently recorded for it in UniProt, and no subcellular location has been annotated. The one functional statement available comes from the NCBI Gene summary, which describes FAM135B as predicted to be involved in lipid metabolic process. That prediction was provided by the Alliance of Genome Resources, and it should be read as an inference rather than as a mechanism established by direct experiment.
For researchers, this means the FAM135B protein is best treated as an uncharacterised target. Questions such as where it sits in the cell, which tissues express it, what it binds and how it contributes to lipid handling remain open on the basis of the supplied data. Any FAM135B antibody, FAM135B ELISA kit or recombinant FAM135B protein work therefore sits at the exploratory end of the spectrum, where careful controls and independent confirmation of results are especially valuable.
The gene is named by HGNC as family with sequence similarity 135 member B, and its earlier name was family with sequence similarity 135, member B. It also carries the previous symbol C8ORFK32. Designations of the family with sequence similarity type group genes by sequence relatedness rather than by established biological role, which is consistent with the limited functional knowledge about the FAM135B gene. A mouse ortholog, Fam135b, is recognised, which allows comparative studies of the gene across species.
FAM135B is predicted to be involved in lipid metabolic process, making it a candidate for studies exploring how uncharacterised proteins contribute to lipid handling.
With no curated function or subcellular location annotated, FAM135B is a target for work that aims to define basic localisation, expression and activity.
As a member of the FAM135 family, FAM135B can be studied alongside related family proteins to explore shared and divergent features.
The presence of a mouse ortholog, Fam135b, supports comparative studies of this gene between human and mouse systems.
The function of FAM135B has not been experimentally annotated in UniProt. The NCBI Gene summary states only that it is predicted to be involved in lipid metabolic process, an inference from the Alliance of Genome Resources. Its precise molecular role remains to be established.
The HGNC name is family with sequence similarity 135 member B, and UniProt lists it as Protein FAM135B. The previous symbol is C8ORFK32, and an earlier name was family with sequence similarity 135, member B. Older literature may use these terms.
A mouse ortholog, Fam135b, is recorded for this gene, and the protein belongs to the FAM135 family. The supplied sources do not link FAM135B to a specific disease. Check the datasheet of any product for its validated reactivity.
Other proteins named under the family with sequence similarity convention, which are grouped by naming rather than shared function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q49AJ0; product specifications from Assay Genie datasheets.