MTDH
MTDH (metadherin), also known as LYRIC, 3D3 and AEG-1, is a multifunctional protein that activates NF-kappa-B signalling and promotes tumour cell growth, metastasis and chemoresistance. It also acts as a transcription coactivator and is implicated in hepatocellular carcinoma. Browse Assay Genie's current range of MTDH research reagents below, or read on for the biology behind the target.
MTDH, the protein product of the metadherin gene, activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. It enables NF-kappa-B binding and transcription coactivator activity, and it is involved in the lipopolysaccharide-mediated signalling pathway, positive regulation of intracellular signal transduction and positive regulation of angiogenesis. When expressed ectopically, it down-regulates SLC1A2/EAAT2 promoter activity. It is also annotated with double-stranded RNA binding activity.
In cancer biology, MTDH promotes anchorage-independent growth of immortalised melanocytes and astrocytes, a key component of tumour cell expansion. It promotes lung metastasis and also affects bone and brain metastasis, possibly by enhancing the seeding of tumour cells to the endothelium of the target organ. It also induces chemoresistance. The MTDH gene is implicated in hepatocellular carcinoma, which makes the protein a frequent subject in oncology research.
UniProt records the protein as Protein LYRIC. Its subcellular locations include the endoplasmic reticulum membrane, the nuclear membrane, tight junctions, the nucleolus and the perinuclear region of the cytoplasm. The gene is also known by the names LYRIC, 3D3 and AEG-1. Mouse and rat both carry an orthologous Mtdh gene, so the protein can be studied in common rodent models.
MTDH promotes lung metastasis and influences bone and brain metastasis, possibly by enhancing tumour cell seeding to target-organ endothelium.
MTDH activates NF-kappa-B and binds it as a transcription coactivator, so it is relevant to studies of intracellular signal transduction.
MTDH induces chemoresistance, which makes it a point of interest for work on how tumour cells withstand therapy.
The MTDH gene is implicated in hepatocellular carcinoma and has a role in positive regulation of angiogenesis.
MTDH activates the NF-kappa-B transcription factor and acts as a transcription coactivator. It promotes anchorage-independent growth, lung metastasis and chemoresistance, and it takes part in positive regulation of angiogenesis and intracellular signal transduction. Check the datasheet of any product for its validated reactivity.
The HGNC name is metadherin. Aliases are LYRIC, 3D3 and AEG-1, and UniProt lists the protein as Protein LYRIC. These names all refer to the same gene, so it helps to search under each one when you review the literature.
Yes. Mouse and rat each have an orthologue named Mtdh, so the protein can be studied in rodent models. The human MTDH gene is also implicated in hepatocellular carcinoma. Check the datasheet of any product for its validated reactivity.
Pathway partners and cancer-related targets that connect to MTDH biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86UE4; product specifications from Assay Genie datasheets.