SRSF4
SRSF4 (serine and arginine rich splicing factor 4, also known as SRP75 or SFRS4) is an RNA-binding member of the SR family of splicing factors. It contributes to alternative splice site selection during pre-mRNA splicing and localises to nuclear speckles. Browse Assay Genie's current range of SRSF4 research reagents below, or read on for the biology behind the target.
SRSF4 plays a role in alternative splice site selection during pre-mRNA splicing. It enables RNA binding activity and is involved in the negative regulation of mRNA splicing via the spliceosome. One specific activity described for the protein is repression of the splicing of MAPT/Tau exon 10, which links SRSF4 to the control of how a neuronal transcript is processed.
The SRSF4 protein belongs to the splicing factor SR family. In the HGNC classification it sits within the RNA binding motif containing group and the serine and arginine rich splicing factors group, alongside related proteins such as SRSF1, SRSF2, SRSF3 and SRSF9. Within the cell, SRSF4 is located in nuclear speckles, subnuclear compartments associated with splicing machinery. The mouse ortholog is Srsf4, which is useful for comparative and in vivo work.
The SRSF4 gene was previously named SFRS4 and the protein has also been called SRP75. Earlier descriptive names include splicing factor, arginine/serine-rich 4. NCBI Gene lists SRSF4 as a biomarker of Down syndrome, acute myeloid leukaemia, clear cell renal cell carcinoma and colon adenocarcinoma. These associations make it a point of interest for researchers studying RNA processing in disease, although the source annotations do not define the mechanisms behind them.
SRSF4 takes part in alternative splice site selection during pre-mRNA splicing, making it a relevant factor for studying how splice choices are made.
SRSF4 represses the splicing of MAPT/Tau exon 10, offering a route into the regulation of this specific exon.
SRSF4 is located in nuclear speckles, so it is useful for examining the organisation of splicing factors within the nucleus.
SRSF4 is reported as a biomarker of Down syndrome, acute myeloid leukaemia, clear cell renal cell carcinoma and colon adenocarcinoma.
SRSF4 is a splicing factor that plays a role in alternative splice site selection during pre-mRNA splicing. It binds RNA, negatively regulates mRNA splicing via the spliceosome, and represses the splicing of MAPT/Tau exon 10. It is found in nuclear speckles.
SRSF4 is also known as SRP75, and its previous gene symbol was SFRS4. Older names include splicing factor, arginine/serine-rich 4 and serine/arginine-rich splicing factor 4. The current HGNC name is serine and arginine rich splicing factor 4.
NCBI Gene describes SRSF4 as a biomarker of Down syndrome, acute myeloid leukaemia, clear cell renal cell carcinoma and colon adenocarcinoma. A mouse ortholog, Srsf4, exists. Check the datasheet of any product for its validated reactivity.
Other serine and arginine rich splicing factors that act alongside SRSF4 in pre-mRNA processing.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08170; product specifications from Assay Genie datasheets.