SLC2A2
SLC2A2 (solute carrier family 2 member 2, also known as GLUT-2 or GLUT2) is a facilitative hexose transporter in the plasma membrane. It mediates the transport of glucose, fructose and galactose, and has been proposed to act as a glucose sensor. Browse Assay Genie's current range of SLC2A2 research reagents below, or read on for the biology behind the target.
SLC2A2 is a facilitative hexose transporter that mediates the transport of glucose, fructose and galactose across the plasma membrane. It is thought to mediate the bidirectional transfer of glucose in hepatocytes and to be responsible for glucose uptake by pancreatic beta cells, where it may form part of the glucose-sensing mechanism. It may also work alongside the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. In addition, the protein can transport dehydroascorbate and urate.
The SLC2A2 gene encodes an integral plasma membrane glycoprotein found in the liver, islet beta cells, intestine and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested to serve as a glucose sensor. Alternative splicing of the gene results in multiple transcript variants. The protein belongs to the major facilitator superfamily, in the sugar transporter family (TC 2.A.1.1) and the glucose transporter subfamily. Mouse and rat orthologs are both named Slc2a2.
The gene is a member of the HGNC solute carrier family 2 group and was previously named solute carrier family 2 (facilitated glucose transporter), member 2. The protein is commonly referred to as GLUT-2 or GLUT2. Mutations in the SLC2A2 gene are associated with susceptibility to disease, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM), which makes it a frequent subject in studies of glucose handling.
SLC2A2 mediates glucose uptake by beta cells and may form part of their glucose-sensing mechanism, making it relevant to studies of islet biology.
The transporter is thought to mediate bidirectional glucose transfer across the plasma membrane of hepatocytes, supporting research into liver glucose handling.
SLC2A2 may act with the Na(+)/glucose cotransporter in transcellular glucose transport in small intestine and kidney epithelium.
Mutations in SLC2A2 are associated with Fanconi-Bickel syndrome and susceptibility to noninsulin-dependent diabetes mellitus, motivating disease-focused work.
SLC2A2 is a facilitative hexose transporter that moves glucose, fructose and galactose across the plasma membrane. It likely mediates bidirectional glucose transfer in hepatocytes, takes up glucose in beta cells and may contribute to glucose sensing. It can also transport dehydroascorbate and urate.
SLC2A2 is also known as GLUT-2 or GLUT2. Its HGNC full name is solute carrier family 2 member 2, previously solute carrier family 2 (facilitated glucose transporter), member 2. Alternative splicing of the gene produces multiple transcript variants.
Yes. According to the NCBI Gene summary, mutations in SLC2A2 are associated with susceptibility to disease, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus. Mouse and rat both have an Slc2a2 ortholog; check the datasheet of any product for its validated reactivity.
Other solute carrier transporters and membrane transport proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11168; product specifications from Assay Genie datasheets.