SDF4
SDF4 (stromal cell derived factor 4) is a member of the CREC protein family that contains six EF-hand calcium-binding motifs. It is also known as Cab45 and as the 45 kDa calcium-binding protein, and it localises to the Golgi lumen. Browse Assay Genie's current range of SDF4 research reagents below, or read on for the biology behind the target.
SDF4 is a calcium-binding protein that localises to the lumen of the Golgi apparatus. According to the NCBI Gene summary, it may be involved in regulating calcium-dependent cellular activities. The protein contains six EF-hand motifs and further calcium-binding motifs, which are the structural features that define its capacity to bind calcium within the secretory pathway.
The SDF4 gene encodes a stromal cell derived factor and belongs to the CREC protein family, as recorded by both HGNC and UniProt. In addition to its main Golgi lumen location, UniProt lists the protein in the cytoplasm, at the cell membrane and in cell projection blebs. UniProt also notes that isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. Orthologous genes are named Sdf4 in both mouse and rat.
The protein is known by several names: SDF4 is the approved gene symbol, Cab45 is the established alias, and UniProt names the product 45 kDa calcium-binding protein. The name stromal cell derived factor 4 is shared by gene naming convention with other stromal cell derived factor genes, but the protein is a distinct member of the CREC family and should not be confused with the chemokine SDF-1. Researchers studying SDF4, whether through an SDF4 antibody, an SDF4 ELISA kit or recombinant SDF4 protein, typically do so in the context of Golgi calcium handling and secretory pathway biology.
SDF4 is a Golgi lumen protein with six EF-hand motifs that may regulate calcium-dependent cellular activities.
As a CREC family member resident in the Golgi, SDF4 is a candidate for studying calcium-dependent events in the secretory pathway.
UniProt reports that isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
SDF4 can be studied alongside other CREC family calcium-binding proteins to compare localisation and function.
SDF4 is a calcium-binding protein of the Golgi lumen with six EF-hand motifs. The NCBI Gene summary states that it may be involved in regulating calcium-dependent cellular activities. UniProt adds that isoform 5 may be involved in zymogen exocytosis by pancreatic acini.
Yes. Cab45 is an alias of SDF4, and UniProt lists the protein as the 45 kDa calcium-binding protein. It is unrelated to the chemokine SDF-1, despite the shared stromal cell derived factor name. UniProt describes at least five isoforms of the protein.
Yes, orthologous genes named Sdf4 exist in both mouse and rat. This makes rodent models relevant to Golgi calcium research. Researchers should check the datasheet of any product for its validated reactivity.
Other stromal cell derived factor targets that are sometimes confused with, or studied alongside, SDF4.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BRK5; product specifications from Assay Genie datasheets.