KIF4A
KIF4A (kinesin family member 4A) is an iron-sulfur cluster binding, microtubule-based motor protein that acts in chromosome segregation during mitosis. It is also known as KIF4, KIF4-G1 and MRX100, and belongs to the chromokinesin subfamily of kinesins. Browse Assay Genie's current range of KIF4A research reagents below, or read on for the biology behind the target.
KIF4A is an ATP-dependent, microtubule-based motor protein with a role in chromosome segregation during mitosis. It translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition. This step is essential for forming an organised central spindle midzone and midbody, and for successful cytokinesis. KIF4A may also contribute to mitotic chromosomal positioning and bipolar spindle stabilisation. UniProt describes it as an iron-sulfur (Fe-S) cluster binding motor protein.
The KIF4A gene encodes a member of the kinesin 4 subfamily of kinesin-related proteins. The protein belongs to the TRAFAC class myosin-kinesin ATPase superfamily, within the kinesin family and chromokinesin subfamily. It associates with condensed chromosome arms and may help maintain chromosome integrity during mitosis. It has also been linked to the intracellular transport of membranous organelles. Reported subcellular locations include the nucleus matrix, cytoplasm, spindle, midbody and chromosomes. A pseudogene of this gene is found on chromosome X.
The gene is also referred to as KIF4, KIF4-G1, HSA271784 and MRX100, and the mouse ortholog is named Kif4. HGNC places KIF4A in the kinesins gene group. Researchers studying mitosis, spindle organisation and cytokinesis often use KIF4A antibody, KIF4A ELISA kit and KIF4A protein reagents to examine where and when this chromokinesin acts.
KIF4A has a role in chromosome segregation during mitosis and may help maintain chromosome integrity on condensed chromosome arms.
KIF4A moves PRC1 to the plus ends of interdigitating spindle microtubules, supporting an organised central spindle midzone.
Formation of the midbody and successful cytokinesis depend on KIF4A-mediated PRC1 translocation at the metaphase to anaphase transition.
As an ATP-dependent microtubule motor, KIF4A is studied for intracellular transport of membranous organelles and spindle stabilisation.
KIF4A is a microtubule-based motor protein that functions in chromosome segregation during mitosis. It translocates PRC1 to the plus ends of interdigitating spindle microtubules at the metaphase to anaphase transition, which is needed for the central spindle midzone, the midbody and cytokinesis.
KIF4A, kinesin family member 4A, is also called chromosome-associated kinesin KIF4A. Aliases and previous symbols include KIF4-G1, KIF4, HSA271784, MRX100, FLJ12530, FLJ12655, FLJ14204 and FLJ20631. HGNC lists it in the kinesins gene group.
A mouse ortholog, Kif4, is recorded for the human gene. Check the datasheet of any product for its validated reactivity. KIF4A belongs to the chromokinesin subfamily of the kinesin family, and a pseudogene of the human gene is found on chromosome X.
Other kinesin family members, including mitotic motors, and related cytoskeletal transport targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95239; product specifications from Assay Genie datasheets.