ZBTB3
ZBTB3 (zinc finger and BTB domain containing 3, also known as FLJ23392) is a nuclear protein that may be involved in transcriptional regulation. It belongs to the C2H2-type zinc finger and BTB domain-containing gene groups. Browse Assay Genie's current range of ZBTB3 research reagents below, or read on for the biology behind the target.
ZBTB3 is annotated in UniProt as a protein that may be involved in transcriptional regulation. The function has not been fully characterised experimentally. The NCBI Gene summary, based on predictions from the Alliance of Genome Resources, says that ZBTB3 is predicted to enable DNA-binding transcription factor activity specific to RNA polymerase II. It is also predicted to be involved in regulating transcription by RNA polymerase II.
The protein is encoded by the ZBTB3 gene and is localised to the nucleus, where it is predicted to be active. The full name, zinc finger and BTB domain containing 3, reflects its domain architecture. HGNC places it in two gene groups: C2H2-type zinc fingers and BTB domain containing proteins. The C2H2 zinc finger group is a large set of proteins commonly associated with DNA binding. The mouse ortholog is designated Zbtb3.
The gene has also been listed under the alias FLJ23392. Because the available functional annotation is limited and largely predicted, ZBTB3 is a useful subject for studies that aim to define which genes it regulates, how it engages DNA, and how it relates to other members of the ZBTB family. Researchers working with the ZBTB3 protein or the ZBTB3 gene should treat its transcriptional role as a working hypothesis to be tested.
ZBTB3 may be involved in transcriptional regulation and is predicted to act as an RNA polymerase II-specific DNA-binding transcription factor.
ZBTB3 is predicted to be active in the nucleus, making its localisation and nuclear function a focus for cell biology work.
As a BTB domain and C2H2 zinc finger protein, ZBTB3 can be compared with other ZBTB family members to explore shared and distinct roles.
Its function is largely predicted, so experimental work on ZBTB3 can help confirm or refine its annotated role in gene regulation.
UniProt states that ZBTB3 may be involved in transcriptional regulation. NCBI Gene adds that it is predicted to enable RNA polymerase II-specific DNA-binding transcription factor activity and to be active in the nucleus. These roles are predictions rather than fully established findings.
The HGNC full name is zinc finger and BTB domain containing 3, and UniProt lists the protein as zinc finger and BTB domain-containing protein 3. The alias FLJ23392 has also been used. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Zbtb3, is recorded for the human gene. No rat ortholog is given in the data supplied here. Check the datasheet of any product for its validated reactivity before choosing a model system.
Other ZBTB family zinc finger and BTB domain transcription regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H5J0; product specifications from Assay Genie datasheets.