SRI
SRI (sorcin) is a calcium-binding protein with multiple EF-hand domains that modulates excitation-contraction coupling in the heart. It contributes to calcium homeostasis in the sarcoplasmic reticulum and regulates the activity of RYR2 calcium channels. Browse Assay Genie's current range of SRI research reagents below, or read on for the biology behind the target.
SRI, also called sorcin, is a calcium-binding protein that modulates excitation-contraction coupling in the heart. It contributes to calcium homeostasis in the cardiac sarcoplasmic reticulum and modulates the activity of RYR2 calcium channels, the release channels that control calcium flux during cardiac contraction. Researchers studying cardiac calcium handling therefore often investigate the SRI protein alongside RYR2.
The SRI gene encodes a protein with multiple E-F hand domains and belongs to the HGNC group of EF-hand domain containing proteins. According to the NCBI Gene summary, the protein relocates from the cytoplasm to the sarcoplasmic reticulum when intracellular calcium levels rise. This calcium-dependent change in location is consistent with its annotated subcellular locations, which are the cytoplasm and the sarcoplasmic reticulum membrane.
Alternative splicing of the SRI gene results in multiple transcript variants that encode distinct proteins, and multiple pseudogenes exist for this gene. Both points are worth bearing in mind when designing experiments or interpreting results. A mouse ortholog, Sri, is recognised. In addition to its role in regulating intracellular calcium homeostasis, SRI's effect on excitation-contraction coupling makes it a relevant target in cardiac physiology and calcium signalling research.
SRI contributes to calcium homeostasis in the heart sarcoplasmic reticulum, making it relevant to studies of intracellular calcium regulation.
SRI modulates excitation-contraction coupling in the heart, so it is studied in work on how calcium signals drive cardiac contraction.
SRI modulates the activity of RYR2 calcium channels, linking it to research on sarcoplasmic reticulum calcium release.
SRI relocates from the cytoplasm to the sarcoplasmic reticulum when calcium rises, offering a model for calcium-triggered protein redistribution.
SRI (sorcin) is a calcium-binding protein that modulates excitation-contraction coupling in the heart. It contributes to calcium homeostasis in the sarcoplasmic reticulum and modulates the activity of RYR2 calcium channels. It also regulates intracellular calcium homeostasis more broadly, according to the NCBI Gene summary.
The HGNC-approved name is sorcin, and UniProt uses the same protein name. No other aliases or previous symbols are listed. Alternative splicing of the SRI gene produces multiple transcript variants that encode distinct proteins, and multiple pseudogenes also exist.
A mouse ortholog, Sri, is recognised for the human SRI gene, which allows comparable calcium-handling questions to be studied in mouse models. Check the datasheet of any product for its validated reactivity before choosing a species-specific experiment.
RYR2, the calcium channel that SRI modulates, and other calcium-handling targets in cardiac research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30626; product specifications from Assay Genie datasheets.