SLC2A12
SLC2A12, also known as GLUT12 (and previously GLUT8), is an insulin-independent facilitative glucose transporter. It belongs to the solute carrier family 2 and the major facilitator superfamily of sugar transporters. Browse Assay Genie's current range of SLC2A12 research reagents below, or read on for the biology behind the target.
SLC2A12 is an insulin-independent facilitative glucose transporter. It belongs to a family of transporters that catalyse the uptake of sugars through facilitated diffusion, a process in which sugars move across the membrane without a direct requirement for metabolic energy coupling. The SLC2A12 protein is therefore studied as a route for glucose entry that does not depend on insulin signalling.
The SLC2A12 gene encodes a member of the glucose transporter subfamily of the sugar transporter family (TC 2.A.1.1), which sits within the major facilitator superfamily. Members of this family show conservation of 12 transmembrane helices, as well as functionally significant amino acid residues. UniProt records the protein in the cell membrane, the endomembrane system and the perinuclear region of the cytoplasm. The mouse ortholog is Slc2a12.
HGNC classifies the gene within the solute carrier family 2 group, and its approved name is solute carrier family 2 member 12. Earlier nomenclature described it as solute carrier family 2 (facilitated glucose transporter), member 12. The protein is commonly called GLUT12, and GLUT8 is listed as a previous symbol, so literature searches should cover both names to avoid missing relevant work.
SLC2A12 catalyses sugar uptake by facilitated diffusion, making it a subject of study in cellular glucose handling.
As an insulin-independent facilitative glucose transporter, SLC2A12 is relevant to work on glucose entry routes outside insulin signalling.
SLC2A12 shares the 12 transmembrane helix architecture of the major facilitator superfamily, supporting structure and function comparisons.
UniProt places SLC2A12 in the cell membrane, endomembrane system and perinuclear cytoplasm, which suits localisation and trafficking questions.
SLC2A12 is an insulin-independent facilitative glucose transporter. It belongs to a family of transporters that catalyse the uptake of sugars through facilitated diffusion across membranes. UniProt places it in the cell membrane, the endomembrane system and the perinuclear region of the cytoplasm.
GLUT12 is the common protein name for SLC2A12. GLUT8 is listed by HGNC as a previous symbol for the same gene. The approved name is solute carrier family 2 member 12, formerly solute carrier family 2 (facilitated glucose transporter), member 12.
A mouse ortholog, Slc2a12, is recorded for this gene. The wider transporter family shows conservation of 12 transmembrane helices and functionally significant residues. Check the datasheet of any product for its validated reactivity.
Other solute carrier transporters and membrane transport proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TD20; product specifications from Assay Genie datasheets.