MS4A4A
MS4A4A (membrane spanning 4-domains A4A) is a membrane protein of the MS4A family that may take part in signal transduction as a component of a multimeric receptor complex. It is also known as CD20L1, MS4A7 and MS4A4. Browse Assay Genie's current range of MS4A4A research reagents below, or read on for the biology behind the target.
MS4A4A is a membrane protein that may be involved in signal transduction as a component of a multimeric receptor complex. The annotation is cautious: the protein is proposed to work as part of a larger assembly at the membrane, rather than as a stand-alone receptor with a defined ligand.
The MS4A4A gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family share common structural features and similar intron/exon splice boundaries. They show distinct expression patterns in haematopoietic cells and in non-lymphoid tissues, which makes the family of interest for researchers studying cell-type-specific membrane signalling. The MS4A4A gene is also reported to give rise to alternatively spliced transcript variants that encode different isoforms, so the isoform under study is worth considering when designing experiments.
HGNC places the gene in the membrane spanning 4-domains group. The protein has appeared under several names, including CD20L1, MS4A7 and MS4A4, and earlier nomenclature described it as membrane-spanning 4-domains, subfamily A, member 4. Checking these aliases is useful when searching the literature, because older papers may use a different symbol for the same gene. Related MS4A family members, such as MS4A2, share the same overall family architecture and are often considered alongside MS4A4A in comparative work.
MS4A4A may act as a component of a multimeric receptor complex, so it is relevant to studies of how membrane assemblies transduce signals.
As a member of the MS4A family, it supports comparative work on shared structural features and distinct expression across family members.
MS4A family members show unique expression patterns in haematopoietic cells, making MS4A4A a candidate for studies of cell-type-specific expression.
The family is also expressed in non-lymphoid tissues, so MS4A4A is relevant to research on tissue-restricted expression beyond the immune system.
MS4A4A is a membrane protein that may be involved in signal transduction as a component of a multimeric receptor complex. This role is described as possible rather than established, and the protein belongs to the MS4A family of membrane-spanning 4-domains proteins.
MS4A4A is also known as CD20L1, MS4A7 and MS4A4. Earlier names described it as membrane-spanning 4-domains, subfamily A, member 4. The gene is reported to produce alternatively spliced transcript variants that encode different isoforms.
MS4A4A belongs to the MS4A family, whose members share structural features and similar intron/exon splice boundaries. The source data do not specify mouse or rat orthologs, so check the datasheet of any product for its validated reactivity.
Other MS4A family members and membrane signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96JQ5; product specifications from Assay Genie datasheets.