SCGN
SCGN (secretagogin, EF-hand calcium binding protein) is a secreted calcium-binding protein that is also found in the cytoplasm. It is also known as SECRET, SEGN, CALBL and DJ501N12.8, and is related to calbindin D-28K and calretinin. Browse Assay Genie's current range of SCGN research reagents below, or read on for the biology behind the target.
SCGN, or secretagogin, is a calcium-binding protein. According to the NCBI Gene summary, the encoded protein is secreted yet is also found in the cytoplasm. UniProt lists its subcellular locations as the cytoplasm, the extracellular space (secreted) and the membrane of secretory vesicles. The protein is thought to be involved in KCl-stimulated calcium flux and in cell proliferation, which places it among the proteins that link calcium signalling to cellular responses.
SCGN is related to calbindin D-28K and calretinin, two other calcium-binding proteins. HGNC classifies the gene in the EF-hand domain containing group, a large collection of proteins that bind calcium through helix-loop-helix motifs. The human SCGN gene sits at 6p22.2, and the protein is recorded in UniProt under accession O76038. Orthologous genes, named Scgn, are annotated in both mouse and rat, so the protein can be studied in common rodent models.
The gene has gone by several names. Alongside the approved symbol SCGN, the aliases SECRET, SEGN, CALBL and DJ501N12.8 appear in the literature and in genomic records. Researchers looking for an SCGN antibody, SCGN ELISA kit or SCGN protein may therefore find the same target listed under these alternative names.
SCGN is an EF-hand calcium-binding protein thought to participate in KCl-stimulated calcium flux, making it relevant to studies of calcium handling.
The NCBI Gene summary links SCGN to cell proliferation, so it is a candidate for work on how calcium-binding proteins influence cell growth.
SCGN is found in the cytoplasm, in secretory vesicle membranes and as a secreted protein, which suits studies of calcium-binding proteins that act outside the cell.
Its relationship to calbindin D-28K and calretinin allows SCGN to be compared with related calcium-binding proteins in the EF-hand group.
SCGN is a calcium-binding protein that is secreted and also found in the cytoplasm. It is thought to be involved in KCl-stimulated calcium flux and in cell proliferation. Beyond this, the source annotation does not describe further specific functions.
SCGN stands for secretagogin, EF-hand calcium binding protein. Aliases include SECRET, SEGN, CALBL and DJ501N12.8. These names refer to the same human gene, which HGNC lists under the identifier HGNC:16941 and NCBI under Gene ID 10590.
Yes. Orthologous genes named Scgn are annotated in both mouse and rat. SCGN is also related to calbindin D-28K and calretinin within the wider group of EF-hand calcium-binding proteins. Check the datasheet of any product for its validated reactivity.
Other EF-hand calcium-binding proteins, including calbindin D-28K and calretinin, which are related to SCGN.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O76038; product specifications from Assay Genie datasheets.