MAP4K5
MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) is a cytoplasmic serine/threonine protein kinase of the STE20 subfamily. Also known as KHS1, GCKR and KHS, it is thought to act upstream of the JUN N-terminal pathway in the response to environmental stress. Browse Assay Genie's current range of MAP4K5 research reagents below, or read on for the biology behind the target.
MAP4K5 is a serine/threonine protein kinase that may play a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway, and the kinase was shown to activate Jun kinase in mammalian cells, which points to a function in stress signalling. As a member of the MAP4K family, it sits near the beginning of mitogen-activated protein kinase signal cascades.
The MAP4K5 gene encodes a protein that is highly similar to yeast SPS1/STE20 kinase. In yeast, SPS1/STE20 functions near the start of the MAP kinase cascades that are essential for the pheromone response. UniProt places the human protein in the protein kinase superfamily, within the STE Ser/Thr protein kinase family and the STE20 subfamily. HGNC classifies it in the MAP4K family, GCK-I subfamily. The protein is located in the cytoplasm. Two alternatively spliced transcript variants of the gene have been described, and both encode the same protein. The mouse ortholog is Map4k5.
The symbol MAP4K5 is used alongside the aliases KHS1, GCKR and KHS, which may be encountered in older literature. Researchers studying the MAP4K5 gene or protein usually do so in the context of stress-activated kinase signalling and the regulation of the JUN N-terminal kinase pathway.
MAP4K5 may contribute to the cellular response to environmental stress, making it a candidate for studies of stress-activated kinase pathways.
The kinase appears to act upstream of the JUN N-terminal pathway and activates Jun kinase in mammalian cells.
As a MAP4K family member similar to yeast SPS1/STE20, MAP4K5 is relevant to how MAP kinase cascades are initiated.
MAP4K5 belongs to the GCK-I subfamily of the STE20 kinases, supporting comparative work across related MAP4K proteins.
MAP4K5 is a serine/threonine protein kinase that may play a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway and was shown to activate Jun kinase in mammalian cells, suggesting a role in stress signalling.
MAP4K5 is also known as KHS1, GCKR and KHS, and its full name is mitogen-activated protein kinase kinase kinase kinase 5. Two alternatively spliced transcript variants have been described, and both encode the same protein.
MAP4K5 is highly similar to yeast SPS1/STE20 kinase, which acts near the start of MAP kinase cascades in the yeast pheromone response. A mouse ortholog, Map4k5, exists. Check the datasheet of any product for its validated reactivity.
Other MAP4K family members and MAP kinase cascade kinases involved in stress signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y4K4; product specifications from Assay Genie datasheets.