GATA5
GATA5 (GATA binding protein 5, also known as GATAS or bB379O24.1) is a nuclear transcription factor with two GATA-type zinc fingers. It is required during cardiovascular development and contributes to the transcriptional programmes behind smooth muscle cell diversity. Browse Assay Genie's current range of GATA5 research reagents below, or read on for the biology behind the target.
GATA5 is a transcription factor that is required during cardiovascular development. It plays an important role in the transcriptional programmes that underlie smooth muscle cell diversity. The protein binds DNA, and it has been shown to bind the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. In other organisms, similar proteins may be involved in establishing cardiac smooth muscle cell diversity.
The GATA5 gene encodes a protein containing two GATA-type zinc fingers, the DNA-binding feature that gives the GATA family its name. The protein is localised to the nucleus, consistent with its role in regulating gene expression. HGNC places it in the GATA zinc finger domain containing gene group, alongside GATA1, GATA2, GATA3, GATA4 and GATA6. The mouse ortholog is Gata5.
The encoded protein is known to bind hepatocyte nuclear factor-1alpha (HNF-1alpha). This interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter, which links GATA5 to transcriptional control in the intestine as well as in the cardiovascular system. Researchers studying the GATA5 gene or protein will often examine it alongside other GATA family members, and the previous name, GATA-binding protein 5, still appears in older literature.
GATA5 is required during cardiovascular development, making it a relevant factor for studies of how the heart and vasculature are formed.
GATA5 contributes to the transcriptional programmes that underlie smooth muscle cell diversity, and similar proteins in other organisms may help establish cardiac smooth muscle diversity.
GATA5 binds the CEF-1 site in the cardiac troponin C enhancer, offering a model for studying GATA-dependent enhancer activity.
GATA5 binds HNF-1alpha, and this interaction cooperatively activates the intestinal lactase-phlorizin hydrolase promoter.
GATA5 is a nuclear transcription factor required during cardiovascular development. It contributes to the transcriptional programmes underlying smooth muscle cell diversity and binds the CEF-1 site in the cardiac troponin C enhancer. It also binds HNF-1alpha to activate the intestinal lactase-phlorizin hydrolase promoter.
HGNC lists the full name as GATA binding protein 5, with the previous name GATA-binding protein 5. Aliases and previous symbols include GATAS and bB379O24.1. UniProt names the protein Transcription factor GATA-5. Searching under any of these names may be useful when reviewing the literature.
A mouse ortholog, Gata5, is recorded. The NCBI summary notes that similar proteins in other organisms may help establish cardiac smooth muscle cell diversity. Within the human GATA zinc finger domain containing group, related members include GATA1, GATA2, GATA3, GATA4 and GATA6. Check the datasheet of any product for its validated reactivity.
Other GATA family transcription factors with products at Assay Genie, including those studied in cardiovascular development.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BWX5; product specifications from Assay Genie datasheets.