LMO7
LMO7 (LIM domain 7, also known as FBX20, FBXO20 or KIAA0858) is a human protein that contains a calponin homology domain, a PDZ domain and a LIM domain. It is thought to take part in protein-protein interactions. Browse Assay Genie's current range of LMO7 research reagents below, or read on for the biology behind the target.
The LMO7 gene encodes a protein built from several recognised modular domains: a calponin homology (CH) domain, a PDZ domain and a LIM domain. According to the NCBI Gene summary, this domain composition suggests that LMO7 may be involved in protein-protein interactions. No catalytic activity, enzyme classification or subcellular location is annotated in the sources used for this page, so its functional role is best described through its domain architecture rather than a defined mechanism.
LMO7 is classed by HGNC in two gene groups: LIM domain containing and PDZ domain containing. The human LMO7 gene sits at 13q22.2 and encodes the protein LIM domain only protein 7 (UniProt Q8WWI1). Researchers searching the literature may also meet it under the aliases FBX20, FBXO20 and KIAA0858, and the previous HGNC name was LIM domain only 7.
The NCBI Gene summary reports that several alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some variants is not known. This matters when choosing reagents for LMO7 work: an LMO7 antibody or other detection tool may recognise only some isoforms, depending on the region it targets. LMO7 belongs to a wider set of LIM domain proteins that includes LMO2, LMO3 and LMO4, which share the LIM domain feature but are separate genes.
The CH, PDZ and LIM domains of LMO7 suggest a role in protein-protein interactions, making it a candidate for interaction mapping.
Several alternatively spliced transcript variants encode different LMO7 isoforms, so isoform-specific expression and detection remain open research questions.
LMO7 is a member of the LIM domain containing gene group, and is useful for comparing LIM-containing proteins.
As a PDZ domain containing protein, LMO7 is relevant to studies of modular scaffolding and domain-mediated binding.
The NCBI Gene summary states that LMO7 encodes a protein with a calponin homology domain, a PDZ domain and a LIM domain, and that it may be involved in protein-protein interactions. No enzymatic activity or detailed functional annotation is given in the sources used here.
LMO7 is also known as FBX20, FBXO20 and KIAA0858. Its full name is LIM domain 7, and UniProt lists LIM domain only protein 7. Several alternatively spliced transcript variants encoding different isoforms have been reported, though the full-length nature of some is unknown.
LMO7 shares the LIM domain feature with LMO2, LMO3 and LMO4, but it is a distinct gene. It also contains calponin homology and PDZ domains, and HGNC places it in both the LIM domain containing and PDZ domain containing groups.
Other LIM domain only proteins with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WWI1; product specifications from Assay Genie datasheets.