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NXF3
NXF3 (nuclear RNA export factor 3) is a member of the NXF family of nuclear RNA export factors. It may function as a tissue-specific nuclear mRNA export factor, and it differs from other family members in its domain features. Browse Assay Genie's current range of NXF3 research reagents below, or read on for the biology behind the target.
NXF3 may function as a tissue-specific nuclear mRNA export factor. Export factors of this kind help move messenger RNA from the nucleus to the cytoplasm, a step that links transcription to translation. The annotation for NXF3 is cautious, and its precise role in mRNA export is still described as a possibility rather than a firmly established activity.
The NXF3 gene is one member of a family of nuclear RNA export factor genes. Common features of the family are a noncanonical RNP-type RNA-binding domain (RBD), four leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain and a ubiquitin-associated domain. The NTF2-like domain allows heterodimerisation with NTF2-related export protein-1 (NXT1), while the ubiquitin-associated domain mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing appears to be a common mechanism in this gene family.
The NXF3 protein departs from this general pattern. It has shortened LRR and ubiquitin-associated domains, and its RBD is unable to bind RNA. It is found in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus, and UniProt also lists a cytoplasmic location. These differences make NXF3 a useful point of comparison with NXF1 when studying how domain architecture shapes export function within the NXF family.
NXF3 is proposed to act as a tissue-specific nuclear mRNA export factor, making it relevant to studies of how mRNA transport is regulated.
NXF3 has shortened LRR and ubiquitin-associated domains and an RBD that cannot bind RNA, so it informs structure-function work across the family.
NXF3 localises to the nucleoplasm, not the nuclear envelope or nucleolus, which makes it a subject for nuclear distribution studies.
Alternative splicing appears common in the NXF gene family, so NXF3 is relevant to work on how isoform variation shapes export factor diversity.
NXF3 may function as a tissue-specific nuclear mRNA export factor, according to UniProt. Its RNA-binding domain is unable to bind RNA, and its LRR and ubiquitin-associated domains are shortened, so its mechanism may differ from that of other NXF family members.
The approved name is nuclear RNA export factor 3, with the gene symbol NXF3. No alternative symbols or previous names are listed. NCBI Gene reports it in the nucleoplasm, not at the nuclear envelope or nucleolus, and UniProt lists nucleus and cytoplasm.
NXF3 belongs to the NXF family, whose members typically share an RBD, four LRRs, an NTF2-like domain binding NXT1, and a ubiquitin-associated domain. NXF3 has shortened LRR and ubiquitin-associated domains. NXF1 is a related family member.
Other nuclear RNA export factors from the NXF family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H4D5; product specifications from Assay Genie datasheets.
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