FNDC3B
FNDC3B (fibronectin type III domain containing 3B, also known as FAD104) is a membrane protein of the FNDC3 family. It may act as a positive regulator of adipogenesis and is annotated with RNA binding activity. Browse Assay Genie's current range of FNDC3B research reagents below, or read on for the biology behind the target.
FNDC3B is annotated in UniProt as a protein that may be a positive regulator of adipogenesis, the process by which precursor cells develop into fat cells. The evidence supplied describes this role cautiously, and the molecular mechanism is not defined in the source annotation. Researchers studying fat cell differentiation may therefore encounter FNDC3B as a candidate factor in that pathway.
The NCBI Gene summary states that the FNDC3B gene enables RNA binding activity. It is predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation, substrate adhesion-dependent cell spreading and type II pneumocyte differentiation. The protein is predicted to be located in the endoplasmic reticulum, while UniProt lists its subcellular location as membrane. These annotations place FNDC3B at the intersection of cell differentiation and cell adhesion biology.
The protein belongs to the FNDC3 family and to the HGNC gene group of fibronectin type III domain containing proteins. Besides FNDC3B, the protein is known by the alias FAD104, and the gene has also been catalogued under the identifiers DKFZp762K137, FLJ23399, PRO4979 and YVTM2421. A mouse ortholog, Fndc3b, is recognised, which allows the biology to be examined in murine systems.
FNDC3B may be a positive regulator of adipogenesis, making it a candidate for studies of fat cell differentiation.
FNDC3B is predicted to act in negative regulation of osteoblast differentiation, linking it to bone cell biology.
FNDC3B is predicted to act within substrate adhesion-dependent cell spreading, relevant to studies of cell-matrix interactions.
FNDC3B enables RNA binding activity and is predicted to act in type II pneumocyte differentiation.
UniProt annotates FNDC3B as a protein that may be a positive regulator of adipogenesis. NCBI Gene adds that it enables RNA binding activity and is predicted to act in osteoblast differentiation, cell spreading and type II pneumocyte differentiation.
FNDC3B stands for fibronectin type III domain containing 3B. Its alias is FAD104, and other identifiers used for the gene include DKFZp762K137, FLJ23399, PRO4979 and YVTM2421. UniProt lists the protein as Fibronectin type III domain-containing protein 3B.
A mouse ortholog, Fndc3b, is recognised, so the gene can be studied in murine models. FNDC3B also belongs to the FNDC3 family. For antibody or assay reactivity, check the datasheet of any product for its validated reactivity.
Other fibronectin type III domain proteins, adipogenesis markers and osteoblast regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q53EP0; product specifications from Assay Genie datasheets.