LILRB5
LILRB5 (leukocyte immunoglobulin-like receptor subfamily B member 5, also known as LIR-8, LIR8 or CD85c) is a membrane receptor of the leukocyte immunoglobulin-like receptor family. It may act as a receptor for class I MHC antigens. Browse Assay Genie's current range of LILRB5 research reagents below, or read on for the biology behind the target.
LILRB5 is a membrane receptor that, according to UniProt, may act as a receptor for class I MHC antigens. It belongs to the subfamily B class of leukocyte immunoglobulin-like receptors (LIRs). Members of this subfamily contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
Several other LIR subfamily B receptors are expressed on immune cells, where they bind MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. This provides the functional context in which LILRB5 is studied, although the specific role of LILRB5 itself is less well defined and is described only as a possible class I MHC receptor.
The LILRB5 gene is part of the LIR gene cluster on chromosome 19q13.4. Multiple transcript variants encoding different isoforms have been reported for this gene. The protein is also known as LIR-8, LIR8 and CD85c, and HGNC places it in the CD molecules group and the inhibitory leukocyte immunoglobulin like receptors group. Its previous name was leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5. Researchers working with LILRB5 often consider it alongside other subfamily B members such as LILRB1, LILRB2, LILRB3 and LILRB4.
LIR subfamily B receptors bind MHC class I on antigen-presenting cells and inhibit immune stimulation, making LILRB5 relevant to inhibitory receptor studies.
LILRB5 may act as a receptor for class I MHC antigens, a question that supports ligand-binding and specificity research.
Subfamily B receptors carry cytoplasmic ITIMs, so LILRB5 is of interest in studies of inhibitory signalling motifs.
The LIR genes cluster at 19q13.4 and encode multiple isoforms, supporting comparative work across the leukocyte immunoglobulin-like receptor family.
UniProt states that LILRB5 may act as a receptor for class I MHC antigens. Related subfamily B receptors on immune cells bind MHC class I on antigen-presenting cells and inhibit stimulation of an immune response. The precise function of LILRB5 itself is less clearly defined.
LILRB5 is also called LIR-8, LIR8 and CD85c. Its earlier name was leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5. NCBI Gene reports multiple transcript variants that encode different isoforms.
LILRB5 is a member of the LIR family, whose genes lie in a cluster at 19q13.4. It belongs to subfamily B, whose members have a transmembrane domain, two to four extracellular immunoglobulin domains and cytoplasmic ITIMs. Check the datasheet of any product for its validated reactivity.
Other inhibitory leukocyte immunoglobulin-like receptors of subfamily B with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75023; product specifications from Assay Genie datasheets.