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BCOR
BCOR (BCL6 corepressor) is a nuclear transcriptional corepressor that was identified through its interaction with the transcription repressor BCL6. It is also known as FLJ20285 and KIAA1575, and was previously named BCL6 co-repressor. Browse Assay Genie's current range of BCOR research reagents below, or read on for the biology behind the target.
BCOR is a transcriptional corepressor. It may specifically inhibit gene expression when it is recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression is thought to be mediated at least in part by histone deacetylase activities that can associate with the corepressor. Specific class I and II histone deacetylases (HDACs) have been shown to interact with BCOR, which suggests a possible link between the two classes of HDACs.
The BCOR gene was first described as encoding an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor required for germinal centre formation that may influence apoptosis. BCOR selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins tested. HGNC places the gene in the ankyrin repeat domain containing group, and UniProt assigns the protein to the BCOR family. The protein localises to the nucleus, and the mouse ortholog is Bcor. Several transcript variants encoding different isoforms have been reported, and a pseudogene of this gene is found on chromosome Y.
BCOR also represses TFAP2A. In doing so it impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Through this repression, BCOR acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells, a function that implies inhibition of histone H3 lysine 4 trimethylation (H3K4me3) and lysine 36 dimethylation (H3K36me2). These links to histone modification make the BCOR gene and protein a useful subject for studies of chromatin-based gene silencing.
BCOR is a corepressor recruited to promoters by DNA-binding proteins such as BCL6 and MLLT3, making it a model for studying targeted gene silencing.
BCOR interacts with specific class I and II HDACs, offering a route to study how the two HDAC classes may be linked.
BCOR binds the POZ domain of BCL6, a repressor required for germinal centre formation that may influence apoptosis.
Through repression of TFAP2A, BCOR negatively regulates osteo-dentiogenic capacity in adult stem cells and involves histone H3 methylation marks.
BCOR is a nuclear transcriptional corepressor. When recruited to promoters by DNA-binding proteins such as BCL6 and MLLT3, it may inhibit gene expression, at least partly through associated histone deacetylase activities. It also represses TFAP2A in adult stem cells.
BCOR stands for BCL6 corepressor, also written BCL6 co-repressor, and UniProt lists it as BCL-6 corepressor. Aliases include FLJ20285 and KIAA1575. NCBI Gene reports that several transcript variants encode different isoforms.
The mouse ortholog is called Bcor. In humans the gene lies on the X chromosome, and a pseudogene is found on chromosome Y. Check the datasheet of any product for its validated reactivity.
BCL6, histone deacetylases, TFAP2A and other transcriptional regulators connected to BCOR corepressor function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6W2J9; product specifications from Assay Genie datasheets.
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