SBSN
SBSN (suprabasin) is a secreted human protein encoded by the SBSN gene on chromosome 19. It is also known by the aliases UNQ698 and HLAR698, and it is annotated as present in extracellular exosomes. Browse Assay Genie's current range of SBSN research reagents below, or read on for the biology behind the target.
SBSN, or suprabasin, is a human protein that UniProt classifies as secreted. The curated sources used for this page do not currently provide a detailed functional annotation, mechanism or interaction partners for SBSN, so this page confines itself to what is firmly established: its identity, its location and its genomic context. Researchers studying the SBSN protein should consult the primary literature for functional work.
The SBSN gene lies at chromosome locus 19q13.12 and is recorded under HGNC:24950, NCBI Gene ID 374897 and UniProt accession Q6UWP8. The encoded protein is 590 amino acids long, with a calculated mass of about 60.5 kDa. HGNC approves the name suprabasin, and the gene has also been catalogued under the identifiers UNQ698 and HLAR698. HGNC lists no gene group and no previous names for SBSN, and no EC number applies, so SBSN is not annotated as an enzyme.
The NCBI Gene summary, provided by the Alliance of Genome Resources, states that SBSN is located in extracellular exosome. That localisation is consistent with the UniProt annotation of the protein as secreted, and it makes SBSN a candidate of interest for work on extracellular vesicle content and secreted proteins. The mouse ortholog is named Sbsn, which allows comparative studies between human and mouse systems. Assay Genie lists SBSN so that researchers can find tools for detecting and studying this gene and its protein product, such as an SBSN antibody or SBSN ELISA kit, where these exist for the target.
SBSN is annotated as located in extracellular exosome, so it is relevant to studies of exosome-associated proteins.
UniProt lists SBSN as secreted, making it a subject for work on proteins released into the extracellular space.
The mouse ortholog Sbsn allows human SBSN findings to be compared with murine models and expression data.
The SBSN gene at 19q13.12, with aliases UNQ698 and HLAR698, is a target for functional annotation and genomic studies.
The sources used here give no detailed functional annotation for SBSN. What is established is that suprabasin is a secreted protein and that it is located in extracellular exosomes. Its precise biological role should be confirmed from the primary literature rather than inferred from its name.
SBSN is the approved HGNC symbol for suprabasin. The aliases UNQ698 and HLAR698 are also recorded for the gene. HGNC lists no previous names. The UniProt entry for the protein is Q6UWP8, and the NCBI Gene ID is 374897.
Yes, the mouse ortholog is named Sbsn, so the gene is conserved between human and mouse. A rat ortholog is not specified in the data used here. Check the datasheet of any product for its validated reactivity.
Exosome-associated proteins and extracellular vesicle markers that may be studied alongside SBSN.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UWP8; product specifications from Assay Genie datasheets.