TMPRSS6
TMPRSS6 (transmembrane serine protease 6, also known as MT2 and FLJ30744) is a membrane-bound serine protease that cleaves cell surface hemojuvelin. Through this activity it contributes to iron homeostasis. Browse Assay Genie's current range of TMPRSS6 research reagents below, or read on for the biology behind the target.
TMPRSS6 is a membrane-bound serine protease. It cleaves cell surface hemojuvelin (HJV), a regulator of expression of the iron absorption-regulating hormone hepcidin (HAMP). By acting on HJV, TMPRSS6 plays a role in iron homeostasis, which makes it a frequent subject in studies of how hepcidin signalling is controlled at the cell surface.
The protein encoded by the TMPRSS6 gene is a type II transmembrane serine proteinase attached to the cell surface, and UniProt lists its subcellular location as the cell membrane. It belongs to the peptidase S1 family and is assigned EC 3.4.21.-. HGNC places it in the type II transmembrane serine proteases group and in the SEA domain containing group. The NCBI Gene summary notes that the encoded protein may also be involved in matrix remodelling processes in the liver, and that alternative splicing produces multiple transcript variants. A mouse ortholog, Tmprss6, is recognised.
The gene was previously named transmembrane protease, serine 6, and is also known by the aliases MT2 and FLJ30744. Researchers working on the TMPRSS6 protein typically examine its relationship with hemojuvelin and hepcidin when investigating iron regulation, and may use a TMPRSS6 antibody or a TMPRSS6 ELISA kit to study expression and protein levels in their model systems.
TMPRSS6 plays a role in iron homeostasis, making it a central protease for studying how iron balance is maintained.
By cleaving hemojuvelin, TMPRSS6 influences expression of hepcidin/HAMP, the hormone that regulates iron absorption.
A type II transmembrane serine protease of the peptidase S1 family, useful for studying membrane-anchored proteolysis.
The encoded protein may be involved in matrix remodelling processes in the liver, an area for further investigation.
TMPRSS6 is a membrane-bound serine protease that cleaves cell surface hemojuvelin (HJV), a regulator of expression of the hormone hepcidin/HAMP. Through this cleavage it plays a role in iron homeostasis. The NCBI Gene summary also suggests involvement in matrix remodelling in the liver.
The HGNC full name is transmembrane serine protease 6, and UniProt lists transmembrane protease serine 6. The previous name was transmembrane protease, serine 6, and aliases include MT2 and FLJ30744. Alternative splicing of the gene results in multiple transcript variants.
A mouse ortholog, Tmprss6, is recognised, so the protein can be studied in mouse models. A rat ortholog is not given in the source data. Check the datasheet of any product for its validated reactivity.
Other type II transmembrane serine proteases, plus hemojuvelin and hepcidin, which are linked to TMPRSS6 in iron regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IU80; product specifications from Assay Genie datasheets.