MAP1LC3A
MAP1LC3A (microtubule associated protein 1 light chain 3 alpha, also known as LC3, LC3A, ATG8E, MAP1ALC3 and MAP1BLC3) is a ubiquitin-like modifier of the ATG8 family that contributes to the formation of autophagosomes. It is also a light chain subunit of the microtubule-associated proteins MAP1A and MAP1B. Browse Assay Genie's current range of MAP1LC3A research reagents below, or read on for the biology behind the target.
MAP1LC3A is a ubiquitin-like modifier involved in the formation of autophagosomal vacuoles, or autophagosomes. Within the ATG8 family, the LC3 proteins are involved in elongation of the phagophore membrane, whereas the GABARAP/GATE-16 subfamily is essential for a later stage of autophagosome maturation. MAP1LC3A also takes part in selective autophagy of the endoplasmic reticulum. Through its interaction with the reticulophagy receptor TEX264, it participates in remodelling subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress. These autophagosomes then fuse with lysosomes, resulting in endoplasmic reticulum turnover.
The MAP1LC3A gene encodes a protein that localises to the autophagosome membrane, the endomembrane system and the cytoskeleton. Its place in the cytoskeleton reflects its original identification as a light chain subunit of MAP1A and MAP1B. These microtubule-associated proteins mediate physical interactions between microtubules and components of the cytoskeleton, and each consists of a heavy chain and several light chains. MAP1LC3A can associate with either MAP1A or MAP1B. HGNC places it in the autophagy related group and the microtubule associated protein 1 light chain 3 family. The symbol LC3 is used as a general alias, and ATG8E reflects its membership of the ATG8 family.
Two transcript variants encoding different isoforms have been described. Expression of variant 1 is suppressed in many tumour cell lines, which suggests that MAP1LC3A may be involved in carcinogenesis. Orthologues exist in mouse and rat, both named Map1lc3a, so the target can be studied in common rodent models.
MAP1LC3A is a ubiquitin-like modifier involved in autophagosome formation and in elongation of the phagophore membrane.
Through TEX264, MAP1LC3A helps remodel endoplasmic reticulum subdomains into autophagosomes under nutrient stress, followed by lysosomal fusion.
As a light chain of MAP1A and MAP1B, MAP1LC3A links studies of microtubule-associated proteins to autophagy.
Suppressed expression of variant 1 in many tumour cell lines suggests MAP1LC3A may be involved in carcinogenesis.
MAP1LC3A is a ubiquitin-like modifier involved in forming autophagosomes. LC3 proteins contribute to elongation of the phagophore membrane. With the receptor TEX264, it helps convert endoplasmic reticulum subdomains into autophagosomes during nutrient stress, leading to lysosomal turnover of the endoplasmic reticulum.
Aliases include LC3, LC3A, ATG8E, MAP1ALC3 and MAP1BLC3. The protein is a light chain subunit of MAP1A and MAP1B. Two transcript variants encoding different isoforms have been reported, and variant 1 expression is suppressed in many tumour cell lines.
Mouse and rat both have an orthologue named Map1lc3a. The protein belongs to the ATG8 family, whose members act in autophagosome formation and maturation. Check the datasheet of any product for its validated reactivity.
Microtubule-associated proteins and other MAP-named signalling proteins with pages at Assay Genie, alongside autophagy-related targets.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H492; product specifications from Assay Genie datasheets.