SLC2A13
SLC2A13, also known as HMIT, is the proton myo-inositol cotransporter, a plasma membrane protein that moves myo-inositol across the membrane coupled to protons. It belongs to the solute carrier family 2 and the major facilitator superfamily of sugar transporters. Browse Assay Genie's current range of SLC2A13 research reagents below, or read on for the biology behind the target.
SLC2A13 functions as an H(+)-myo-inositol cotransporter. It couples the movement of myo-inositol to protons, and it can also transport related stereoisomers. NCBI Gene annotation describes myo-inositol:proton symporter activity as its core molecular function and lists involvement in myo-inositol transport.
The protein is a member of the major facilitator superfamily and the sugar transporter family (TC 2.A.1.1). UniProt records it in the cell membrane, and NCBI Gene places it in the plasma membrane and the cell body. The SLC2A13 gene is the human member of solute carrier family 2 and has orthologues named Slc2a13 in mouse and rat.
Beyond transport, NCBI Gene annotates SLC2A13 with ATPase binding and protease binding activities, and with a role in the positive regulation of amyloid-beta formation. This makes the HMIT transporter of interest to researchers studying inositol handling and amyloid-related processes. Its earlier HGNC name, solute carrier family 2 (facilitated glucose transporter), member 13, reflects its place among the facilitated sugar transporters, although its annotated activity is proton-coupled myo-inositol transport.
SLC2A13 is a proton-coupled myo-inositol symporter, so it is a focal point for studying how myo-inositol and related stereoisomers cross cell membranes.
NCBI Gene annotates SLC2A13 as involved in positive regulation of amyloid-beta formation, linking this transporter to amyloid-related cell biology.
As a solute carrier family 2 member in the sugar transporter family, SLC2A13 offers a comparison point for substrate selectivity among facilitated transporters.
Annotated ATPase binding and protease binding activities make SLC2A13 relevant to studies of protein interactions at the plasma membrane.
SLC2A13 is an H(+)-myo-inositol cotransporter. It carries myo-inositol across the plasma membrane together with protons, and it can also transport related stereoisomers. NCBI Gene also lists involvement in myo-inositol transport and positive regulation of amyloid-beta formation.
SLC2A13 is the HGNC symbol for solute carrier family 2 member 13. HMIT is a listed alias, and UniProt names the protein proton myo-inositol cotransporter. The previous HGNC name was solute carrier family 2 (facilitated glucose transporter), member 13.
Yes. The mouse and rat orthologues are both named Slc2a13. The protein belongs to the major facilitator superfamily, sugar transporter family. For any product, check the datasheet for its validated reactivity.
Other solute carrier transporters with products at Assay Genie, spanning amino acid, monocarboxylate, cation-chloride and vesicular transporters.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96QE2; product specifications from Assay Genie datasheets.