NMS
NMS (neuromedin S) is a secreted neuropeptide belonging to the NmU family. It is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Browse Assay Genie's current range of NMS research reagents below, or read on for the biology behind the target.
NMS is a neuropeptide that UniProt describes as implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. The protein is secreted, so it can act on the cell that produces it or on neighbouring cells. Research on the NMS protein therefore centres on how a secreted signalling peptide contributes to the timing of biological rhythms.
The NMS gene encodes a preproprotein. This is proteolytically processed to generate a biologically active neuropeptide. According to the NCBI Gene summary, the mature peptide plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action and cardiovascular function. It is also linked to the stimulation of oxytocin and vasopressin release. These roles make neuromedin S a useful subject for studies that connect neuropeptide signalling with appetite, fluid balance and cardiovascular physiology.
NMS belongs to the NmU family and is classed by HGNC in the neuropeptides gene group. It is a member of the wider neuromedin family of neuropeptides. Orthologues of the human gene are present in mouse and rat, both named Nms, which allows the biology of neuromedin S to be examined in common rodent models. Researchers studying the NMS gene or its peptide product often do so alongside other members of the neuromedin family.
NMS is implicated in regulating circadian rhythms through autocrine and/or paracrine actions, making it relevant to studies of biological timekeeping.
The mature neuropeptide has an anorexigenic action, so NMS is of interest in research on the control of feeding.
NMS is associated with stimulation of oxytocin and vasopressin release, linking it to neuroendocrine signalling and antidiuretic function.
NCBI Gene lists cardiovascular function among the processes regulated by neuromedin S, supporting its study in cardiovascular research.
NMS encodes neuromedin S, a secreted neuropeptide implicated in regulating circadian rhythms through autocrine and/or paracrine actions. NCBI Gene also associates it with anorexigenic and antidiuretic action, cardiovascular function, and stimulation of oxytocin and vasopressin release.
The NMS gene encodes a preproprotein. This is proteolytically processed to generate the biologically active neuropeptide. The protein is secreted and belongs to the NmU family, within the wider neuromedin family of neuropeptides.
Yes. The source data lists orthologues of human NMS in both mouse and rat, each named Nms. This allows rodent models to be used for neuromedin S research. Check the datasheet of any product for its validated reactivity.
Other neuromedin family neuropeptides, their receptors and neuroendocrine hormones linked to NMS biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5H8A3; product specifications from Assay Genie datasheets.