RTL1
RTL1 (retrotransposon Gag like 1, also known as PEG11, MART1, Mar1, SIRH2 and HUR1) is a membrane protein encoded by a retrotransposon-derived imprinted gene. It plays an essential role in the capillary endothelial cells of the feto-maternal interface and in placental development. Browse Assay Genie's current range of RTL1 research reagents below, or read on for the biology behind the target.
RTL1 plays an essential role in capillary endothelial cells, where it contributes to the maintenance of the feto-maternal interface and to development of the placenta. The NCBI Gene summary describes the gene as essential for maintenance of the foetal capillaries, which makes RTL1 a useful subject for studies of placental biology and foetal vascular integrity.
The RTL1 gene is a retrotransposon-derived, paternally expressed imprinted gene. It is highly expressed at the late foetal stage in both the fetus and the placenta. The protein is annotated as a membrane protein and belongs to the retrotransposon Gag like family in the HGNC classification. Its mouse ortholog is Rtl1, and other family members include RTL6 and RTL9.
The locus has an unusual regulatory arrangement. An overlapping, maternally expressed antisense transcript carries several microRNAs that target the RTL1 transcripts through an RNA interference (RNAi) mechanism. This pairing of sense and antisense transcripts is central to how RTL1 dosage is controlled in imprinted tissues. The gene was previously named retrotransposon-like 1, and the symbols PEG11, MART1, Mar1, SIRH2 and HUR1 appear in the literature, so it helps to search under all of these names when reviewing earlier work.
RTL1 is required for placental development and for maintaining the feto-maternal interface, making it a relevant target in placental biology.
The gene is essential for maintenance of foetal capillaries, and the protein acts in capillary endothelial cells.
RTL1 is a paternally expressed imprinted gene with an overlapping maternally expressed antisense transcript, offering a model for imprinting studies.
Several microRNAs in the antisense transcript target RTL1 transcripts through RNA interference, providing an example of sense-antisense regulation.
RTL1 plays an essential role in capillary endothelial cells for the maintenance of the feto-maternal interface and for placental development. The NCBI Gene summary also states that the gene is essential for maintenance of the foetal capillaries, and that it is highly expressed at the late foetal stage.
RTL1 is the HGNC symbol for retrotransposon Gag like 1. Aliases and previous symbols include PEG11, MART1, Mar1, SIRH2 and HUR1, and the previous name was retrotransposon-like 1. UniProt lists the protein as Retrotransposon-like protein 1.
A mouse ortholog, Rtl1, is recorded for this gene. RTL1 is a retrotransposon-derived, paternally expressed imprinted gene. An overlapping maternally expressed antisense transcript carries microRNAs that target RTL1 transcripts by RNAi. Check the datasheet of any product for its validated reactivity.
Other members of the retrotransposon Gag like family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A6NKG5; product specifications from Assay Genie datasheets.