UACA
UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats, also known as FLJ10128 and KIAA1561) is a multi-domain protein that modulates isoactin dynamics and is linked to the regulation of apoptosis. It belongs to the N-Ank protein group. Browse Assay Genie's current range of UACA research reagents below, or read on for the biology behind the target.
UACA modulates isoactin dynamics to regulate the morphological changes that cells need for growth and motility. Its interaction with ARF6 may modulate cell shape and motility after injury, and it may also be involved in the formation of multiple neurites. The protein is found in the nucleus, the cytoplasm and the cytoskeleton, which fits with a role that links cytoskeletal remodelling to wider cell-state decisions.
The UACA gene encodes a protein that contains ankyrin repeats and coiled-coil domains, features reflected in its name, and HGNC places it in the N-Ank proteins group. The NCBI Gene summary indicates that it likely plays a role in apoptosis. Studies in rodents have implicated the protein in stimulating apoptosis and in regulating mammary gland involution, the process by which the mammary gland returns to its pre-pregnant state. The mouse ortholog is Uaca.
Experiments in human cell lines point the other way. In those studies UACA was proposed to negatively regulate apoptosis by interacting with PRKC apoptosis WT1 regulator protein (PAR-4) and inhibiting translocation of the PAR-4 receptor. UACA is therefore a useful protein for studying how apoptotic signalling and cytoskeletal dynamics intersect.
The name reflects its history as an autoantigen: autoantibodies to UACA have been identified in patients with panuveitis and Graves' disease. Differential expression of the gene has also been observed in various human cancers. The gene is also listed under the aliases FLJ10128 and KIAA1561, which is useful when searching older literature on the UACA protein.
UACA is proposed to stimulate or inhibit apoptosis depending on context, including through its interaction with PAR-4 in human cell lines.
UACA modulates isoactin dynamics and, with ARF6, may influence cell shape and motility after injury.
Autoantibodies to UACA have been identified in patients with panuveitis and Graves' disease, making it a focus in autoimmune studies.
Differential UACA expression is seen in various human cancers, and rodent work links it to mammary gland involution.
UACA modulates isoactin dynamics to regulate the cell shape changes needed for growth and motility. Its interaction with ARF6 may modulate shape and motility after injury, and it may contribute to multiple neurite formation. It is also implicated in apoptosis, with reports of both stimulating and inhibiting it.
UACA stands for uveal autoantigen with coiled-coil domains and ankyrin repeats. Aliases include FLJ10128 and KIAA1561. HGNC lists no previous names, and classes the protein in the N-Ank proteins group. Use these aliases when searching older literature on the UACA gene.
Autoantibodies to UACA have been identified in patients with panuveitis and Graves' disease, and differential expression of the gene has been observed in various human cancers. A mouse ortholog, Uaca, has been used in rodent studies of apoptosis and mammary gland involution.
Interaction partners, actin isoforms and apoptosis regulators connected to UACA biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BZF9; product specifications from Assay Genie datasheets.