LSAMP
LSAMP (limbic system-associated membrane protein, also known as LAMP or IGLON3) is a neuronal cell-surface glycoprotein of the IgLON family. It mediates selective neuronal growth and axon targeting, particularly in the developing limbic system. Browse Assay Genie's current range of LSAMP research reagents below, or read on for the biology behind the target.
LSAMP mediates selective neuronal growth and axon targeting. It contributes to the guidance of developing axons and to the remodelling of mature circuits in the limbic system, and it is essential for normal growth of the hippocampal mossy fibre projection. The NCBI Gene summary describes it as a protein that may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system.
The human LSAMP gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family, which belongs to the immunoglobulin superfamily. HGNC classifies it within the I-set domain containing group and the IgLON cell adhesion molecules. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein that sits at the cell membrane. Alternative splicing produces multiple transcript variants, at least one of which encodes a preproprotein that undergoes this processing. Orthologues are present in mouse and rat, both named Lsamp.
The protein is also known as LAMP and IGLON3, and its name reflects its original association with the limbic system. Beyond neural development, the encoded protein may function as a tumour suppressor and may play a role in neuropsychiatric disorders, which makes the LSAMP protein a subject of interest in both neuroscience and cancer research.
LSAMP mediates selective neuronal growth and axon targeting, making it relevant to how developing axons find their targets.
It contributes to guidance of developing axons and remodelling of mature circuits in the limbic system.
LSAMP is essential for normal growth of the hippocampal mossy fibre projection, a focus for circuit formation research.
The encoded protein may act as a tumour suppressor and may play a role in neuropsychiatric disorders.
LSAMP mediates selective neuronal growth and axon targeting. It contributes to the guidance of developing axons and the remodelling of mature circuits in the limbic system, and it is essential for normal growth of the hippocampal mossy fibre projection. It may act as a selective homophilic adhesion molecule.
LSAMP stands for limbic system-associated membrane protein. It is also known as LAMP and IGLON3, the latter reflecting its place in the IgLON family, named after LAMP, OBCAM and neurotrimin. Alternative splicing gives multiple transcript variants, and the preproprotein is proteolytically processed.
The NCBI Gene summary states that LSAMP may function as a tumour suppressor and may play a role in neuropsychiatric disorders. Orthologues exist in mouse and rat, both called Lsamp. Check the datasheet of any product for its validated reactivity.
Other IgLON family members and neuronal adhesion molecules involved in axon guidance.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13449; product specifications from Assay Genie datasheets.