RGS12
RGS12 (regulator of G protein signalling 12) is a member of the RGS gene family that may act as a GTPase-activating protein and as a transcriptional repressor. It behaves as a cell cycle-dependent repressor that promotes inhibition of S-phase DNA synthesis. Browse Assay Genie's current range of RGS12 research reagents below, or read on for the biology behind the target.
RGS12 belongs to the regulators of G-protein signalling, a gene family defined by its role in modulating G protein pathways. According to the NCBI Gene summary, the encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. UniProt describes it as behaving as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. This combination of activities makes the RGS12 protein of interest to researchers studying how G protein signalling connects to cell cycle control.
UniProt records RGS12 in several compartments: the nucleus, the nuclear matrix, the cytoplasm, dendrites and synapses. The RGS12 gene is classified by HGNC within two groups, the regulators of G-protein signalling and the PDZ domain containing proteins. Mouse and rat both carry an orthologous Rgs12 gene, which allows comparative work in rodent systems. Multiple transcript variants encoding distinct isoforms have been identified for the gene, and further alternative splice variants have been described although their biological nature has not been determined.
The NCBI Gene summary notes that RGS12 may play a role in tumorigenesis, though the source does not define the mechanism. HGNC lists the previous name forms regulator of G-protein signalling 12 and regulator of G-protein signalling 12, which you may meet in older literature. RGS12 sits alongside other family members such as RGS1, RGS3, RGS10 and RGS19, each of which has its own profile within the wider RGS family.
RGS12 is an RGS family member that may act as a GTPase-activating protein, so it is studied in the regulation of G protein pathways.
RGS12 behaves as a cell cycle-dependent transcriptional repressor that promotes inhibition of S-phase DNA synthesis.
The NCBI Gene summary indicates RGS12 may play a role in tumorigenesis, making it a candidate for oncology research.
UniProt places RGS12 in dendrites and synapses as well as the nucleus, supporting work on its distribution in neuronal cells.
RGS12 may function as a GTPase-activating protein and as a transcriptional repressor. UniProt reports that it behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. The NCBI Gene summary also suggests it may play a role in tumorigenesis.
Yes. Multiple transcript variants encoding distinct isoforms have been identified for the gene, and other splice variants have been described without a determined biological nature. HGNC lists no alias symbols, only the earlier name forms regulator of G-protein signalling 12 and regulator of G-protein signalling 12.
Mouse and rat each have an orthologous Rgs12 gene, so the protein can be studied in rodent models. Researchers should check the datasheet of any product for its validated reactivity before using it with a particular species.
Other regulator of G protein signalling family members that share pathway context with RGS12.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14924; product specifications from Assay Genie datasheets.