PCGF6
PCGF6 (polycomb group ring finger 6, also known as MBLR or RNF134) is a nuclear transcriptional repressor and a component of a PRC1-like Polycomb complex. It helps maintain the repressed state of many genes, including Hox genes, during development. Browse Assay Genie's current range of PCGF6 research reagents below, or read on for the biology behind the target.
PCGF6 is a transcriptional repressor that acts as a component of a Polycomb group (PcG) multiprotein PRC1-like complex. This class of complex is required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complexes act through chromatin remodelling and histone modification, and mediate monoubiquitination of histone H2A at Lys-119, which renders chromatin heritably changed in its expressibility. Within the PRC1-like complex, PCGF6 regulates the ubiquitin ligase activity of RNF2. It may also modulate levels of histone H3K4Me3 by activating the KDM5D histone demethylase.
The PCGF6 gene encodes a protein that contains a RING finger motif, most closely related to those of the PcG proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors, and PCGF6 has been shown to interact with some of them. The protein is localised to the nucleus. Its activity is regulated by cell cycle dependent phosphorylation, and alternatively spliced transcript variants encoding different isoforms have been identified. Orthologues of the human PCGF6 gene are present in mouse and rat (both Pcgf6).
HGNC classifies PCGF6 within the ring finger proteins and the Polycomb group ring fingers. The gene was previously named ring finger protein 134 (RNF134), and MBLR is a further alias. Researchers studying PCGF6 protein, the PCGF6 gene or PRC1-like complexes can use these names when searching the literature.
PCGF6 is a component of a PRC1-like complex that maintains transcriptional repression of many genes through chromatin modification.
Within the PRC1-like complex, PCGF6 regulates RNF2 ubiquitin ligase activity, which mediates monoubiquitination of histone H2A at Lys-119.
PRC1-like complexes containing PCGF6 help keep Hox genes and many other genes repressed throughout development.
PCGF6 may modulate histone H3K4Me3 levels by activating the KDM5D histone demethylase, linking repression to demethylation.
PCGF6 is a nuclear transcriptional repressor and a component of a PRC1-like Polycomb complex. The complex mediates monoubiquitination of histone H2A at Lys-119 and maintains repression of genes such as Hox genes. PCGF6 regulates RNF2 ubiquitin ligase activity within it.
PCGF6 stands for polycomb group ring finger 6. It is also called MBLR, and its previous symbol and name were RNF134 and ring finger protein 134. The NCBI Gene summary notes that alternatively spliced transcript variants encode different isoforms.
Yes. Its RING finger motif is most closely related to those of the PcG proteins RNF110/MEL-18 and BMI1, and it interacts with some PcG proteins. Mouse and rat both have a Pcgf6 orthologue; check the datasheet of any product for its validated reactivity.
Other Polycomb group proteins, PRC1 components and histone-modifying enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BYE7; product specifications from Assay Genie datasheets.