BTG3
BTG3 (BTG anti-proliferation factor 3, also known as ANA, tob55, APRO4 and ANA/BTG3) is a member of the BTG/Tob family of structurally related proteins with antiproliferative properties. Overexpression of the protein impairs serum-induced cell cycle progression. Browse Assay Genie's current range of BTG3 research reagents below, or read on for the biology behind the target.
BTG3 is an anti-proliferation factor. The UniProt annotation records that overexpression impairs serum-induced cell cycle progression from the G0/G1 phase to S phase, which places the protein as a negative influence on entry into DNA synthesis. This behaviour fits with the wider BTG/Tob family, whose members are structurally related and appear to have antiproliferative properties.
The human BTG3 gene encodes Protein BTG3, which UniProt assigns to the BTG family. HGNC places the gene in the BTG/Tob family. Orthologous genes are named Btg3 in both mouse and rat. According to the NCBI Gene summary, two transcript variants encoding different isoforms have been found for this gene. Subcellular location is not annotated in UniProt, and no tissue expression data are included in the sources used here.
The gene has been known under several names: ANA, tob55, APRO4 and ANA/BTG3, as well as the earlier HGNC names BTG family, member 3 and BTG family member 3. The NCBI Gene summary notes that the encoded protein might play a role in neurogenesis in the central nervous system. Researchers studying cell cycle control, growth suppression or neural development may therefore consider BTG3 alongside other BTG/Tob family proteins when planning BTG3 antibody, BTG3 protein or BTG3 gene expression work.
BTG3 overexpression impairs serum-induced progression from G0/G1 to S phase, making it a subject for studies of how cells enter DNA synthesis.
As a BTG/Tob family member, BTG3 belongs to a group of structurally related proteins that appear to have antiproliferative properties.
The NCBI Gene summary suggests BTG3 might play a role in neurogenesis in the central nervous system.
Two transcript variants encoding different isoforms have been reported for BTG3, relevant to work comparing isoform-specific expression.
BTG3 is an anti-proliferation factor of the BTG/Tob family. UniProt reports that its overexpression impairs serum-induced cell cycle progression from G0/G1 to S phase. The NCBI Gene summary adds that it might play a role in neurogenesis in the central nervous system.
BTG3 is also called ANA, tob55, APRO4 and ANA/BTG3, and was formerly named BTG family, member 3. The NCBI Gene summary reports two transcript variants that encode different isoforms of the protein.
Yes. Orthologous genes named Btg3 exist in mouse and rat, and the protein belongs to the BTG/Tob family of antiproliferative proteins. Check the datasheet of any product for its validated reactivity.
Other BTG/Tob family proteins and antiproliferative factors involved in cell cycle control.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14201; product specifications from Assay Genie datasheets.