SOX1
SOX1 (SRY-box transcription factor 1) is a nuclear transcriptional activator of the SOX family that may act as a switch in neuronal development. It keeps neural cells undifferentiated by counteracting proneural proteins. Browse Assay Genie's current range of SOX1 research reagents below, or read on for the biology behind the target.
SOX1 is a transcriptional activator that may function as a switch in neuronal development. According to UniProt, it keeps neural cells undifferentiated by counteracting the activity of proneural proteins, and in doing so suppresses neuronal differentiation. The NCBI Gene summary adds that the encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. The protein is found in the nucleus, consistent with its role in regulating gene expression.
The SOX1 gene is intronless and encodes a member of the SOX (SRY-related HMG-box) family of transcription factors. This family is involved in the regulation of embryonic development and in the determination of cell fate. HGNC places the gene in the group of SRY-box transcription factors. The mouse ortholog is Sox1, and work in mice shows that a similar protein regulates the gamma-crystallin genes and is essential for lens development.
SOX1 was formerly named SRY (sex determining region Y)-box 1 and SRY-box 1, reflecting its relationship to the sex-determining factor SRY through the shared HMG-box DNA-binding domain. Because it balances maintenance of the undifferentiated neural state against neuronal differentiation, SOX1 is a useful subject for studies of neural development and cell fate decisions. Researchers studying this factor often look at it alongside other SOX family members, which share the HMG-box and contribute to developmental regulation.
SOX1 may act as a switch in neuronal development, making it relevant to studies of how neural cells commit to differentiation.
SOX1 keeps neural cells undifferentiated by counteracting proneural proteins, which is central to research on progenitor state.
As a SOX family member, SOX1 contributes to embryonic development and the determination of cell fate.
In mice, a similar protein regulates gamma-crystallin genes and is essential for lens development, supporting eye development studies.
SOX1 is a transcriptional activator that may function as a switch in neuronal development. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. It may act as an activator after forming a complex with other proteins.
The HGNC full name is SRY-box transcription factor 1, and UniProt lists the protein as Transcription factor SOX-1. Previous names were SRY (sex determining region Y)-box 1 and SRY-box 1. No alternative gene symbols are recorded.
The mouse has an ortholog, Sox1. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. Check the datasheet of any product for its validated reactivity.
Other SOX family transcription factors involved in embryonic development and cell fate determination.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00570; product specifications from Assay Genie datasheets.