OLIG1
OLIG1 (oligodendrocyte transcription factor 1, also known as BHLHB6 or bHLHe21) is a nuclear basic helix-loop-helix transcription factor. It orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis, working together with OLIG2. Browse Assay Genie's current range of OLIG1 research reagents below, or read on for the biology behind the target.
OLIG1 is a transcription factor that orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, it activates the formation of oligodendrocyte precursor cells (OPCs) while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN). It does this through transcriptional regulation of GSX2: mechanistically, OLIG1 binds and silences multiple conserved enhancer elements of GSX2. Together with OLIG2, it also helps to establish the pMN domain of the embryonic neural tube.
The OLIG1 gene encodes a nuclear protein that belongs to the basic helix-loop-helix proteins and the oligodendrocyte transcription factor family. Predictions from the Alliance of Genome Resources indicate that it enables RNA polymerase II-specific DNA-binding transcription factor activity and E-box binding activity, and that it is located in chromatin within the nucleus. It is also predicted to be involved in axon development, positive regulation of transcription by RNA polymerase II, and sensory organ development, and to act upstream of or within neuron fate commitment.
OLIG1 is also known as BHLHB6 and bHLHe21, reflecting its place among the basic helix-loop-helix proteins. Orthologous genes are named Olig1 in both mouse and rat, which makes rodent models a practical route for studying its role in glial development. Researchers studying OLIG1 often examine it alongside OLIG2, its cooperating partner in oligodendrocyte lineage specification.
OLIG1 acts with OLIG2 to activate oligodendrocyte precursor cell formation, making it central to studies of glial progenitor specification.
OLIG1 orchestrates progenitor cell fates during cortical gliogenesis, including repression of olfactory bulb interneuron intermediate progenitor generation.
Together with OLIG2, OLIG1 helps establish the pMN domain of the embryonic neural tube.
OLIG1 is annotated as orchestrating progenitor cell fates during gliomagenesis, linking glial development programmes to tumour biology.
OLIG1 is a transcription factor that orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. With OLIG2 it promotes oligodendrocyte precursor cell formation and represses olfactory bulb interneuron progenitor generation, by binding and silencing conserved enhancer elements of GSX2.
OLIG1 is the HGNC symbol for oligodendrocyte transcription factor 1. It is also known as BHLHB6 and bHLHe21, names that reflect its classification among the basic helix-loop-helix proteins. The same protein is the subject of both OLIG1 gene and OLIG1 protein research.
Yes. Mouse and rat both carry an orthologous gene named Olig1, so rodent systems are commonly used to study its function. Check the datasheet of any product for its validated reactivity.
OLIG2, the cooperating oligodendrocyte transcription factor, and other targets relevant to glial development.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TAK6; product specifications from Assay Genie datasheets.