Erythroferrone
Erythroferrone (ERFE) is a secreted iron-regulatory hormone produced by erythroblasts after blood loss, where it suppresses hepcidin expression in the liver. It is also known as CTRP15, C1QTNF15 and FAM132B, and belongs to the adipolin/erythroferrone family. Browse Assay Genie's current range of Erythroferrone research reagents below, or read on for the biology behind the target.
Erythroferrone is an iron-regulatory hormone that acts as an erythroid regulator after haemorrhage. Erythroblasts produce it following blood loss, and it mediates suppression of hepcidin (HAMP) expression in the liver. Lower hepcidin promotes increased iron absorption and mobilisation from stores. Beyond iron homeostasis, the erythroferrone protein promotes lipid uptake into adipocytes and hepatocytes through transcriptional up-regulation of genes involved in fatty acid uptake.
Erythroferrone also influences several signalling pathways. In cardiomyocytes it inhibits apoptosis and inflammatory response through sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signalling. In hepatocytes it inhibits autophagy induced by nutrient deficiency by promoting phosphorylation of IRS1, AKT and MTOR, activating the AKT-MTOR pathway. In bone, it negatively regulates osteoblast differentiation, potentially by sequestering BMP2, which inhibits SMAD signalling. Reduced BMP2 signalling raises expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, indirectly promoting bone resorption. NCBI Gene annotates molecular sequestering activity and a role in negative regulation of the BMP signalling pathway.
The ERFE gene is grouped by HGNC under C1q and TNF related, and the protein is secreted. The gene has carried the aliases FLJ37034, CTRP15 and C1QTNF15, and its previous name was family with sequence similarity 132, member B (FAM132B). Mouse and rat both have an orthologous Erfe gene, which allows the hormone to be studied in rodent models.
Erythroferrone suppresses hepatic hepcidin expression after blood loss, increasing iron absorption and mobilisation from stores.
Erythroblasts produce erythroferrone following blood loss, making it a marker of erythroid regulation in the response to haemorrhage.
Erythroferrone promotes lipid uptake into adipocytes and hepatocytes and inhibits starvation-induced autophagy in hepatocytes via AKT-MTOR signalling.
Erythroferrone may sequester BMP2 in osteoblasts, inhibiting SMAD signalling and indirectly promoting bone resorption through RANKL and SOST.
Erythroferrone is a secreted hormone made by erythroblasts after blood loss. It suppresses hepcidin (HAMP) expression in the liver, which increases iron absorption and mobilisation from stores. It also affects lipid uptake, cardiomyocyte survival, hepatocyte autophagy and osteoblast differentiation.
The ERFE gene has also been called FLJ37034, CTRP15, C1QTNF15 and FAM132B. The last reflects the previous HGNC name, family with sequence similarity 132, member B. Check the datasheet of any product for the alias used and its validated reactivity.
Yes. Mouse and rat each have an orthologous gene named Erfe. Human erythroferrone belongs to the adipolin/erythroferrone family and is grouped with C1q and TNF related genes. Check the datasheet of any product for its validated reactivity.
Hepcidin, BMP and AKT-MTOR pathway targets connected to erythroferrone biology, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q4G0M1; product specifications from Assay Genie datasheets.