HOXA1
HOXA1 (homeobox A1, also known as HOX1F or HOX1) is a sequence-specific, DNA-binding transcription factor that acts during embryonic development. It helps give cells positional identity along the anterior-posterior axis and contributes to hindbrain segmentation. Browse Assay Genie's current range of HOXA1 research reagents below, or read on for the biology behind the target.
HOXA1 is a sequence-specific transcription factor. It regulates several developmental processes, including development and morphogenesis of the brainstem, inner and outer ear, abducens nerve and cardiovascular system, as well as cognition and behaviour. It is also part of a developmental regulatory system that gives cells specific positional identities on the anterior-posterior axis, and it acts on anterior body structures. HOXA1 seems to act in the maintenance and/or generation of hindbrain segments. It activates transcription in the presence of PBX1A and PKNOX1.
The HOXA1 protein belongs to the Antp homeobox family, Labial subfamily, and is found in the nucleus. In vertebrates, homeobox genes sit in four clusters, A, B, C and D, on separate chromosomes, and their expression is regulated in space and time during embryonic development. The HOXA1 gene is part of the A cluster on chromosome 7. It encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis and differentiation, and that may help place hindbrain segments correctly along the anterior-posterior axis.
Two transcript variants encoding two different isoforms have been reported for the gene, and only one of the isoforms contains the homeodomain region. HGNC classes HOXA1 in the HOXL subclass of homeoboxes and records the previous name homeo box A1. Mouse and rat orthologs are both named Hoxa1, which allows comparative developmental studies across these species.
HOXA1 regulates multiple developmental processes and gives cells positional identity along the anterior-posterior axis, making it a useful model for body-plan patterning.
HOXA1 seems to act in generating and maintaining hindbrain segments and may place them correctly along the anterior-posterior axis.
HOXA1 is implicated in inner and outer ear, abducens nerve, brainstem and cardiovascular development and morphogenesis.
HOXA1 activates transcription in the presence of PBX1A and PKNOX1, so it is relevant to studies of homeodomain cofactor partnerships.
HOXA1 is a sequence-specific transcription factor that regulates development of the brainstem, ears, abducens nerve and cardiovascular system, and influences cognition and behaviour. It helps assign positional identity on the anterior-posterior axis and seems to act in generating and maintaining hindbrain segments.
HOXA1 is also known as HOX1F and HOX1, and its protein name is Homeobox protein Hox-A1. The previous gene name was homeo box A1. Two transcript variants encode two isoforms, and only one of them contains the homeodomain region.
Yes. Mouse and rat both have an ortholog named Hoxa1, and homeobox genes in vertebrates are organised in A, B, C and D clusters. Check the datasheet of any product for its validated reactivity.
Other HOXA cluster homeobox transcription factors involved in developmental patterning.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49639; product specifications from Assay Genie datasheets.