RGS6
RGS6 (regulator of G protein signalling 6) is a member of the RGS family that negatively regulates G protein-coupled receptor signalling. It increases the GTPase activity of G protein alpha subunits, switching them into their inactive GDP-bound state. Browse Assay Genie's current range of RGS6 research reagents below, or read on for the biology behind the target.
RGS6 regulates G protein-coupled receptor signalling cascades. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, which drives them into their inactive GDP-bound form. In complex with GNB5, the RGS6/GNB5 dimer enhances the GTPase activity of GNAO1. The RGS6 protein therefore acts as a brake on signalling downstream of receptor activation.
The RGS6 gene encodes a member of the RGS family, defined by an RGS domain that confers GTPase-activating activity towards certain G alpha subunits. RGS6 also belongs to a subfamily of RGS proteins that carry DEP and GGL domains, the GGL domain being a G beta 5-interacting domain. UniProt records the protein in the cytoplasm, cytosol, nucleus and membrane, including the cell membrane. Mouse and rat both have an Rgs6 ortholog.
RGS proteins negatively regulate G protein signalling, and RGS6 may modulate neuronal, cardiovascular and lymphocytic activities as well as cancer risk. The gene produces many alternatively spliced transcript variants. These encode isoforms with long or short N-terminal domains, complete or incomplete GGL domains and distinct C-terminal domains, although the full-length nature of some variants is not known. HGNC classes RGS6 with the regulators of G-protein signalling, the DEP domain containing group and the microRNA protein coding host genes. Earlier names spell it as regulator of G-protein signalling 6.
RGS6 accelerates GTP hydrolysis by G alpha subunits, making it a useful target for studying how GPCR signalling is switched off.
RGS proteins, including RGS6, may modulate neuronal activity, and the RGS6/GNB5 dimer enhances GNAO1 GTPase activity.
RGS6 belongs to the RGS proteins that may modulate cardiovascular activities through negative regulation of G protein signalling.
RGS proteins such as RGS6 may influence lymphocytic activities and cancer risk, motivating study of their expression and function.
RGS6 inhibits G protein-coupled receptor signalling by increasing the GTPase activity of G protein alpha subunits, which pushes them into the inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. It acts through its RGS domain, which has GTPase-activating activity.
RGS6 has no aliases listed, but earlier names spelled it regulator of G-protein signalling 6 or signalling 6. NCBI Gene describes many alternatively spliced transcript variants. These encode isoforms differing in N-terminal length, GGL domain completeness and C-terminal sequence.
Mouse and rat both carry an Rgs6 ortholog. NCBI Gene notes that RGS proteins may modulate neuronal, cardiovascular and lymphocytic activities and cancer risk. Check the datasheet of any product for its validated reactivity.
Other RGS family members that regulate G protein signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49758; product specifications from Assay Genie datasheets.