DCAF7
DCAF7 (DDB1 and CUL4 associated factor 7, also known as HAN11, SWAN-1 and WDR68) is a WD40-repeat scaffold protein involved in craniofacial development and kinase signalling. It may also act as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex. Browse Assay Genie's current range of DCAF7 research reagents below, or read on for the biology behind the target.
DCAF7 is a protein built from multiple WD40 repeats, a motif that mediates protein-protein interactions and allows the assembly of multiprotein complexes. It has been shown to work as a scaffold protein for complexes involved in kinase signalling. UniProt also notes that it may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex, which fits its place among the DDB1 and CUL4 associated factors.
In development, DCAF7 is involved in craniofacial formation. It acts upstream of the EDN1 pathway and is required for formation of the palatoquadrate, the equivalent of the upper jaw. The activity needed for EDN1 pathway function differs between the first and second arches. DCAF7 associates with DIAPH1 and controls GLI1 transcriptional activity, and it could be involved in normal and disease skin development. The protein is found in the cytoplasm and the nucleus.
The DCAF7 gene belongs to the WD repeat DCAF7 family and is highly conserved, present in eukaryotic plants, fungi and animals. Its ortholog was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation, which explains the earlier name HAN11. The protein has also been called SWAN-1 and WDR68 (WD repeat domain 68). Alternative splicing produces multiple transcript variants. The mouse ortholog is Dcaf7.
DCAF7 is required for palatoquadrate formation and acts upstream of the EDN1 pathway, making it relevant to studies of jaw and arch patterning.
Its WD40 repeats support multiprotein assembly, and DCAF7 functions as a scaffold for protein complexes involved in kinase signalling.
DCAF7 may act as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex, linking it to targeted protein turnover.
DCAF7 associates with DIAPH1, controls GLI1 transcriptional activity and could be involved in normal and disease skin development.
DCAF7 is a WD40-repeat scaffold protein that supports assembly of kinase signalling complexes. It is involved in craniofacial development, acts upstream of the EDN1 pathway, associates with DIAPH1 and controls GLI1 transcriptional activity. It may also serve as a CUL4-DDB1 substrate receptor.
DCAF7 is also known as HAN11, SWAN-1 and WDR68, and its previous HGNC name was WD repeat domain 68. HAN11 reflects the plant ortholog, first identified as a regulator of anthocyanin biosynthesis. Alternative splicing gives multiple transcript variants.
Yes. The gene is highly conserved and present in eukaryotic plants, fungi and animals. The plant ortholog was first found as a regulator of flower pigmentation, and the mouse ortholog is Dcaf7. Check the datasheet of any product for its validated reactivity.
Binding partners, CUL4-DDB1 ligase components and pathway members connected to DCAF7 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P61962; product specifications from Assay Genie datasheets.