NEGR1
NEGR1 (neuronal growth regulator 1) is a cell-surface member of the IgLON family of immunoglobulin superfamily proteins. It is also known as KILON, Ntra and IGLON4, and may act in cell adhesion and in axon sprouting in the mammalian brain. Browse Assay Genie's current range of NEGR1 research reagents below, or read on for the biology behind the target.
NEGR1 may be involved in cell adhesion. UniProt also annotates it as a possible trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. These functions are described with caution in the source annotation, so the exact mechanism remains to be established. The NEGR1 protein is found at the cell membrane.
The NEGR1 gene encodes a member of the immunoglobulin superfamily, placed in the IgLON family. HGNC classifies it within the I-set domain containing group and the IgLON cell adhesion molecules group. The protein is also known as KILON, Ntra and IGLON4, and the gene has also appeared under the symbol MGC46680. Mouse and rat orthologs are both named Negr1.
NCBI Gene summarises NEGR1 as enabling transmembrane transporter binding activity. It acts upstream of or within several processes, including cholesterol homeostasis, protein localisation to plasma membrane raft and regulation of protein stability. Within the cell it is located in the late endosome and at the plasma membrane. Together, these annotations link NEGR1 to both neural cell-surface biology and membrane and lipid-related processes, which makes it a useful target for studies of neuronal adhesion and membrane organisation.
NEGR1 is an IgLON family member that may be involved in cell adhesion, making it relevant to studies of cell-surface interactions.
NEGR1 may function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.
NEGR1 acts upstream of or within cholesterol homeostasis, linking this adhesion molecule to lipid regulation.
NEGR1 is involved in protein localisation to plasma membrane rafts and is found in late endosomes and at the plasma membrane.
UniProt states that NEGR1 may be involved in cell adhesion and may act as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. NCBI Gene adds roles in cholesterol homeostasis, protein localisation to plasma membrane rafts and regulation of protein stability.
NEGR1 stands for neuronal growth regulator 1. Aliases and previous symbols include KILON, MGC46680, Ntra and IGLON4, the last reflecting its place in the IgLON family. UniProt lists the protein as Neuronal growth regulator 1.
Yes. Mouse and rat both have an ortholog named Negr1. Researchers working with these species should check the datasheet of any product for its validated reactivity.
Other IgLON family members and neuronal cell adhesion molecules studied alongside NEGR1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z3B1; product specifications from Assay Genie datasheets.