KLHL17
KLHL17 (kelch like family member 17) is a substrate-recognition component of cullin-RING BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It is expressed in neurons and may contribute to actin-based neuronal function. Browse Assay Genie's current range of KLHL17 research reagents below, or read on for the biology behind the target.
KLHL17 acts as a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. In this role it selects target proteins for ubiquitination. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. KLHL17 may also play a role in actin-based neuronal function.
The KLHL17 protein contains an N-terminal BTB domain, which mediates dimerisation, and a C-terminal Kelch domain, which mediates binding to F-actin. According to the NCBI Gene summary, it is expressed in neurons of most regions of the brain. UniProt lists its subcellular location as the postsynaptic density at the synapse, consistent with a role in neuronal signalling and cytoskeletal regulation. The KLHL17 gene has mouse and rat orthologs, both named Klhl17.
HGNC classifies the gene within the Kelch like and BTB domain containing gene groups. Its previous name was kelch-like 17 (Drosophila). Among related family members are KLHL1, KLHL2, KLHL12, KLHL20 and KLHL29, which share the same BTB-Kelch architecture.
KLHL17 is expressed in neurons across most brain regions and localises to the postsynaptic density, making it relevant to synaptic protein studies.
KLHL17 is a substrate-recognition component of BCR (BTB-CUL3-RBX1) E3 ligase complexes, providing a model for cullin-RING substrate selection.
The BCR(KLHL17) complex mediates ubiquitination and degradation of GLUR6, linking the protein to regulation of this receptor subunit.
The Kelch domain of KLHL17 binds F-actin, and the protein may regulate actin-based neuronal function.
KLHL17 is a substrate-recognition component of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates ubiquitination and subsequent degradation of GLUR6. It may also play a role in actin-based neuronal function, and it localises to the postsynaptic density.
KLHL17 has an N-terminal BTB domain, which mediates dimerisation, and a C-terminal Kelch domain, which mediates binding to F-actin. HGNC places it in the Kelch like and BTB domain containing gene groups. Its previous name was kelch-like 17 (Drosophila).
Yes. The KLHL17 gene has orthologs named Klhl17 in both mouse and rat. This makes rodent models a common route for studying its neuronal functions. Check the datasheet of any product for its validated reactivity.
Other Kelch-like family members with BTB-Kelch architecture and roles in cullin-RING E3 ligase signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6TDP4; product specifications from Assay Genie datasheets.