EDN2
EDN2 (endothelin 2, also known as ET2) is a secreted vasoconstrictor peptide of the endothelin family. It is processed from a preproprotein to a short mature form that acts as a ligand for endothelin receptors. Browse Assay Genie's current range of EDN2 research reagents below, or read on for the biology behind the target.
EDN2 is one of the endothelins, which UniProt describes as endothelium-derived vasoconstrictor peptides. The EDN2 gene encodes a secretory preproprotein that is processed to a short mature peptide. This mature form functions as a ligand for the endothelin receptors, which initiate intracellular signalling events in target cells. Researchers studying this pathway often work with the EDN2 protein alongside its receptors, EDNRA and EDNRB.
The protein is secreted and belongs to the endothelin/sarafotoxin family. HGNC places the gene in the endothelins group, together with related genes such as EDN3. Alternative splicing of the EDN2 gene results in multiple transcript variants. Orthologous genes are annotated in mouse and rat, both named Edn2, which allows the peptide to be studied in common rodent models.
According to the NCBI Gene summary, EDN2 is involved in a wide range of biological processes, including hypertension and ovulation. Altered expression of the gene has also been implicated in tumorigenesis. These links make endothelin 2 a useful subject for work on vascular tone, reproductive biology and cancer, where measuring EDN2 expression or peptide levels with an EDN2 antibody or EDN2 ELISA kit can help define its role.
As an endothelium-derived vasoconstrictor peptide of the endothelin family, EDN2 is relevant to studies of vessel regulation.
EDN2 is involved in hypertension, making it a candidate for investigating endothelin-driven control of blood pressure.
The NCBI Gene summary links EDN2 to ovulation, supporting its study in reproductive physiology.
Altered EDN2 expression is implicated in tumorigenesis, prompting analysis of endothelin signalling in tumour biology.
EDN2 encodes a secreted endothelin peptide with vasoconstrictor activity. The preproprotein is processed to a short mature form that acts as a ligand for endothelin receptors, triggering intracellular signalling. It is involved in processes such as hypertension and ovulation.
EDN2 is the HGNC symbol for endothelin 2, and ET2 is a recognised alias. UniProt lists the protein as Endothelin-2. Alternative splicing of the gene produces multiple transcript variants, and the protein is processed from a preproprotein.
Mouse and rat both carry an ortholog named Edn2. Altered EDN2 expression is implicated in tumorigenesis, and the gene is involved in hypertension and ovulation. Check the datasheet of any product for its validated reactivity.
Other endothelin family members and the endothelin receptors that mediate EDN2 signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P20800; product specifications from Assay Genie datasheets.