TNFRSF21
TNFRSF21 (tumour necrosis factor receptor superfamily member 21, also known as DR6 and CD358) is a cell-membrane death receptor of the TNF receptor superfamily. It promotes apoptosis and regulates T-cell responses, oligodendrocyte survival and pyroptosis. Browse Assay Genie's current range of TNFRSF21 research reagents below, or read on for the biology behind the target.
TNFRSF21 is a member of the tumour necrosis factor receptor superfamily that promotes apoptosis, possibly through a pathway involving activation of NF-kappa-B. It can also promote apoptosis mediated by BAX and by the release of cytochrome c from mitochondria into the cytoplasm. Through its death domain, the receptor interacts with TRADD, an adaptor known to mediate signal transduction by TNF receptors. NCBI Gene reports that the encoded protein activates NF-kappa-B and mitogen-activated protein kinase 8 (JNK1) and induces apoptosis, although UniProt notes it may inhibit JNK activation in response to T-cell stimulation.
The protein has roles well beyond cell death. In the immune system it contributes to signalling cascades triggered by T-cell receptor stimulation and to the regulation of T-cell differentiation and proliferation. It negatively regulates T-cell responses, including the release of cytokines such as IL-4, IL-5, IL-10, IL-13 and IFN-gamma by Th2 cells, and negatively regulates antibody production in response to antigens. Knockout studies in mice suggest a role in T-helper cell activation and a possible involvement in inflammation and immune regulation. In the nervous system, TNFRSF21 negatively regulates oligodendrocyte survival, maturation and myelination. Under trophic-factor deprivation, beta-secretase cleaves surface APP to release sAPP-beta, which is further cleaved to give an N-terminal fragment of APP (N-APP).
TNFRSF21 also regulates pyroptosis: in response to reactive oxygen species and subsequent oxidation, it recruits CASP8, leading to activation of GSDMC. The gene is also known as DR6, and CD358 is its designation in the CD molecule nomenclature. The mouse and rat orthologues are both named Tnfrsf21, which allows comparative work in standard rodent models.
TNFRSF21 promotes apoptosis through NF-kappa-B, BAX and cytochrome c release, making it a useful target for studying death receptor pathways.
The receptor negatively regulates Th2 cytokine release and antibody production, so it is studied in adaptive immunity and T-cell differentiation.
TNFRSF21 negatively regulates oligodendrocyte survival, maturation and myelination, and is linked to APP processing under trophic-factor deprivation.
TNFRSF21 recruits CASP8 in response to reactive oxygen species and activates GSDMC, linking the receptor to pyroptotic cell death.
TNFRSF21 is a death receptor that promotes apoptosis, possibly via NF-kappa-B, and signals through its death domain and TRADD. It also negatively regulates T-cell responses and oligodendrocyte myelination, and recruits CASP8 to activate GSDMC during pyroptosis.
Yes. DR6 (death receptor 6) and CD358 are alternative names for TNFRSF21, the HGNC symbol for TNF receptor superfamily member 21. The older name is tumour necrosis factor receptor superfamily, member 21. Literature may use any of these names for the same gene and protein.
Mouse and rat both carry an orthologue named Tnfrsf21. Mouse knockout studies suggest the gene functions in T-helper cell activation and may be involved in inflammation and immune regulation. Check the datasheet of any product for its validated reactivity.
Other TNF receptor superfamily members, including death receptors and immune-regulating receptors, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75509; product specifications from Assay Genie datasheets.