LAMTOR1
LAMTOR1, also known as p18, Ragulator1, Pdro or C11orf59, is a key component of the Ragulator complex. It anchors the complex to the lysosomal membrane and supports amino acid sensing and activation of mTORC1. Browse Assay Genie's current range of LAMTOR1 research reagents below, or read on for the biology behind the target.
LAMTOR1 is a key component of the Ragulator complex, a multiprotein assembly involved in amino acid sensing and activation of mTORC1. mTORC1 is a signalling complex that promotes cell growth in response to growth factors, energy levels and amino acids. The Ragulator is activated by amino acids through a mechanism involving the lysosomal V-ATPase. It then acts towards the Rag small GTPases (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and RagD/RRAGD) in two ways. It works as a guanine nucleotide exchange factor that activates them, and it mediates their recruitment to the lysosome membrane. Activated Ragulator and Rag GTPases then form a scaffold that recruits mTORC1 to lysosomes, where mTORC1 is in turn activated.
Within the complex, the LAMTOR1 protein is directly responsible for anchoring the Ragulator to the lysosomal membrane. It wraps around the other subunits to hold them in place and interacts with the Rag GTPases, which is central to mTORC1 recruitment. LAMTOR1 is also required for late endosome and lysosome biogenesis. It may regulate receptor recycling through endosomes, and MAPK signalling by recruiting some of its components to late endosomes. It may also contribute to cholesterol homeostasis, regulating LDL uptake and cholesterol release from late endosomes and lysosomes, and may play a role in RHOA activation. Together with FLCN, it is needed to recruit and activate RagC and RagD at lysosomes and to drive embryonic stem cells out of pluripotency through non-canonical, mTOR-independent inactivation of TFE3.
The LAMTOR1 gene belongs to the LAMTOR1 family and is grouped by HGNC with the Ragulator complex. Its previous name was chromosome 11 open reading frame 59, and it is also listed as FLJ20625 and p27RF-Rho. NCBI Gene describes it as part of the FNIP-folliculin RagC/D GAP and as involved in positive regulation of TORC1 signalling and cholesterol transport. Mouse and rat orthologs are both named Lamtor1.
LAMTOR1 anchors the Ragulator to lysosomes and helps recruit mTORC1, making it central to amino acid sensing and growth control.
The protein is required for late endosome and lysosome biogenesis and may regulate receptor recycling through endosomes.
LAMTOR1 may regulate LDL uptake and cholesterol release from late endosomes and lysosomes, linking it to cholesterol transport.
With FLCN, LAMTOR1 activates RagC and RagD at lysosomes to drive exit from pluripotency through non-canonical TFE3 inactivation.
LAMTOR1 anchors the Ragulator complex to the lysosomal membrane. It wraps around the other subunits, interacts with the Rag GTPases and helps recruit mTORC1 to lysosomes, where mTORC1 is activated in response to amino acids. It also supports late endosome and lysosome biogenesis.
LAMTOR1 is also called p18, Ragulator1, Pdro, p27RF-Rho and FLJ20625. Its previous symbol was C11orf59, from the earlier name chromosome 11 open reading frame 59. The current HGNC name is late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.
Yes. Mouse and rat both have an ortholog named Lamtor1. Researchers working with these species should check the datasheet of any product for its validated reactivity.
Other Ragulator complex subunits and related lysosomal signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6IAA8; product specifications from Assay Genie datasheets.