TSC22D3
TSC22D3 (TSC22 domain family member 3, also known as GILZ, DIP, TSC-22R, hDIP and DSIPI) is the anti-inflammatory glucocorticoid-induced leucine zipper protein. It mediates key anti-inflammatory, immunosuppressive and anti-myogenic effects of glucocorticoids. Browse Assay Genie's current range of TSC22D3 research reagents below, or read on for the biology behind the target.
TSC22D3 is best known as a mediator of glucocorticoid action. The gene encodes the glucocorticoid (GC)-induced leucine zipper protein, and its expression is stimulated by glucocorticoids and by interleukin 10. It appears to play a key role in the anti-inflammatory and immunosuppressive effects of these steroids, and it has been shown to inhibit pro-inflammatory molecules, including nuclear factor κB.
The protein also acts in muscle biology. It inhibits myogenic differentiation and mediates the anti-myogenic effects of glucocorticoids by binding and regulating the transcriptional activity of MYOD1 and HDAC1, which results in reduced expression of MYOG. This links one protein to both immune and muscle responses to glucocorticoid exposure. TSC22D3 is found in the cytoplasm and the nucleus, and alternate splicing of the TSC22D3 gene gives multiple transcript variants.
TSC22D3 belongs to the TSC-22/Dip/Bun family and sits in the HGNC TSC22 domain family. Its aliases reflect its history: DIP and DSIPI derive from the previous name delta sleep inducing peptide, immunoreactor, while GILZ describes its glucocorticoid-induced leucine zipper function. The human gene lies on the X chromosome, and orthologues are annotated in mouse and rat as Tsc22d3. Researchers studying glucocorticoid signalling, inflammation and muscle differentiation use TSC22D3 as a readout and a mechanistic target.
TSC22D3 expression is stimulated by glucocorticoids, making it a useful marker for studying how these steroids drive their downstream effects.
The protein contributes to the anti-inflammatory and immunosuppressive effects of glucocorticoids and inhibits pro-inflammatory molecules such as nuclear factor κB.
TSC22D3 inhibits myogenic differentiation by regulating MYOD1 and HDAC1 activity, reducing MYOG expression in response to glucocorticoids.
Because interleukin 10 stimulates TSC22D3 expression, the protein is relevant to studies of anti-inflammatory cytokine pathways.
TSC22D3 mediates anti-inflammatory and immunosuppressive effects of glucocorticoids and can inhibit pro-inflammatory molecules including nuclear factor κB. It also inhibits myogenic differentiation by binding and regulating MYOD1 and HDAC1, which reduces MYOG expression.
The gene is known as GILZ for its glucocorticoid-induced leucine zipper protein. DIP, hDIP and DSIPI come from the earlier name delta sleep inducing peptide, immunoreactor, and TSC-22R reflects its place in the TSC-22 family. Alternate splicing gives multiple transcript variants.
Yes. Mouse and rat both carry an orthologous gene named Tsc22d3. This allows glucocorticoid and inflammation research to be carried out in rodent models. Check the datasheet of any product for its validated reactivity.
Other TSC22 domain family members and tuberous sclerosis complex proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99576; product specifications from Assay Genie datasheets.