MVP
MVP (major vault protein) is the principal structural component of the vault particle, a large ribonucleoprotein complex implicated in cargo transport and signal transduction. It is also known as LRP and VAULT1, and is linked to multidrug resistance. Browse Assay Genie's current range of MVP research reagents below, or read on for the biology behind the target.
MVP is a structural component of the vault particle, a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. The protein oligomerises to form a cage-like vault complex, which can house several minor vault components, including PARP4. Vaults may contribute to nucleo-cytoplasmic transport, consistent with the localisation of the protein to the cytoplasm, the perinuclear region and the nuclear pore complex.
Beyond its architectural role, MVP acts on intracellular signalling. It down-regulates IFNG-mediated STAT1 signalling and the subsequent activation of JAK, and it down-regulates SRC activity and signalling through MAP kinases. The NCBI Gene summary also describes a role in regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt pathways, so the MVP protein may influence several cellular processes.
The MVP gene belongs to the major vault protein family and is also referred to as LRP and VAULT1. Alternatively spliced transcript variants have been observed. MVP is associated with multidrug resistance, and expression of the gene may serve as a prognostic marker for several types of cancer. Mouse and rat both have an Mvp ortholog, which allows the biology of the vault to be studied in common model organisms.
MVP is the main structural subunit that oligomerises into the cage-like vault, which can house minor components such as PARP4.
Vaults may take part in nucleo-cytoplasmic transport, and MVP localises to the nuclear pore complex and perinuclear region.
MVP down-regulates IFNG-mediated STAT1 signalling, SRC activity and MAP kinase signalling, and may regulate the PI3K/Akt pathway.
MVP plays a role in multidrug resistance, and its expression may be a prognostic marker for several types of cancer.
MVP is the major structural component of the vault particle, a ribonucleoprotein complex that may be involved in cargo transport, signal transduction and nucleo-cytoplasmic transport. It also down-regulates IFNG-mediated STAT1 signalling, JAK activation, SRC activity and MAP kinase signalling.
MVP stands for major vault protein and is also known as LRP and VAULT1. It belongs to the major vault protein family. Alternatively spliced transcript variants have been reported for the gene, so check the datasheet of any product for its validated reactivity.
MVP plays a role in multidrug resistance, and its expression may be a prognostic marker for several types of cancer. Orthologs exist in mouse and rat, both named Mvp, so the protein can be studied in these model organisms.
Vault-associated proteins and signalling partners of MVP, including STAT1, JAK, SRC and MAP kinase pathway targets.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14764; product specifications from Assay Genie datasheets.