NPPC
NPPC (natriuretic peptide C), also known as CNP or C-type natriuretic peptide, is a secreted hormone of the natriuretic peptide family. It regulates growth plate chondrocytes during endochondral ossification and may also act on the vasculature. Browse Assay Genie's current range of NPPC research reagents below, or read on for the biology behind the target.
NPPC is a hormone that plays a role in endochondral ossification. It does so by regulating the proliferation and differentiation of chondrocytes in the cartilaginous growth plate. The peptide acts by specifically binding and stimulating NPR2, which produces cGMP. It also binds the clearance receptor NPR3. NPPC may also be vasoactive and natriuretic, which links it to cardiovascular biology as well as skeletal development.
The NPPC gene encodes a preproprotein that is proteolytically processed into several products. These include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, all of which belong to the natriuretic peptide family. The mature peptides are secreted. Researchers working with the NPPC protein therefore need to consider which processed form is relevant to their question. Mouse and rat both carry an orthologous gene, Nppc, so the target can be studied in common laboratory models.
NPPC is classed by HGNC in the natriuretic peptides gene group, and its previous name was natriuretic peptide precursor C. The encoded peptides show vasorelaxation activity in laboratory animals. Elevated levels of CNP-22 have been observed in the plasma of patients with chronic heart failure, which has made the peptide a point of interest in cardiovascular research. Studies of NPPC often examine the NPR2 to cGMP signalling axis and the clearance route through NPR3, whether the focus is bone growth or vascular function.
NPPC regulates proliferation and differentiation of growth plate chondrocytes, making it central to studies of endochondral ossification.
NPPC peptides show vasorelaxation activity in laboratory animals, and CNP-22 is elevated in plasma in chronic heart failure.
NPPC specifically binds and stimulates NPR2 to produce cGMP, providing a model for natriuretic peptide receptor signalling.
NPPC binds the clearance receptor NPR3, so it is relevant to studies of how natriuretic peptide activity is regulated.
NPPC is a secreted hormone that regulates the proliferation and differentiation of growth plate chondrocytes during endochondral ossification. It binds and stimulates NPR2 to produce cGMP, and may also be vasoactive and natriuretic. It also binds the clearance receptor NPR3.
NPPC is also called CNP, C-type natriuretic peptide and, previously, natriuretic peptide precursor C. The gene encodes a preproprotein that is processed into several products, including the peptides CNP-53, CNP-29 and CNP-22.
Elevated plasma CNP-22 has been observed in patients with chronic heart failure. Mouse and rat have an orthologous gene, Nppc. Check the datasheet of any product for its validated reactivity.
Natriuretic peptide receptors, other natriuretic peptide family members and related pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23582; product specifications from Assay Genie datasheets.